Stable association of a pigmentation allele with an oncogene: Nonhybrid melanomas in Xiphophorus variatus

S. Kazianis, R. Borowsky

Research output: Contribution to journalArticle

Abstract

Sex-linked genes in several species of the fish genus Xiphophorus cause macromelanophore pigmentation patterns on the flanks of the fish. Some, but not all, of these patterns can develop into melanomas. The tumorigenic alleles are tightly linked to a supernumerary oncogene sequence, Xmrk. The data show that the association of Xmrk with two of the tumorigenic alleles of X. variatus, P2 and Li, holds over a broad geographic area. From the distribution of the fish and the geology of the area, it is probable that this association is older than the late Tertiary. The persistence of this association suggests that Xmrk confers some benefit on P2- and Li-bearing individuals to offset the deleterious effect. The nature of this benefit remains unknown.

Original languageEnglish (US)
Pages (from-to)199-203
Number of pages5
JournalJournal of Heredity
Volume86
Issue number3
StatePublished - 1995

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Cyprinodontiformes
Melanoma
oncogenes
Pigmentation
melanoma
Fish
Oncogenes
pigmentation
Fishes
Alleles
alleles
Bearings (structural)
fish
Geology
sex linkage
Xiphophorus
geology
Probable
Persistence
Genus

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biotechnology
  • Genetics
  • Molecular Biology
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Genetics(clinical)

Cite this

Stable association of a pigmentation allele with an oncogene : Nonhybrid melanomas in Xiphophorus variatus. / Kazianis, S.; Borowsky, R.

In: Journal of Heredity, Vol. 86, No. 3, 1995, p. 199-203.

Research output: Contribution to journalArticle

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