Stabilisation of self-assembled DNA crystals by triplex-directed photo-cross-linking

Hatem O. Abdallah, Yoel P. Ohayon, Arun Richard Chandrasekaran, Ruojie Sha, Keith R. Fox, Tom Brown, David A. Rusling, Chengde Mao, Nadrian Seeman

Research output: Contribution to journalArticle

Abstract

The tensegrity triangle is a robust DNA motif that can self-assemble to generate macroscopic three-dimensional crystals. However, the stability of these crystals is dependent on the high ionic conditions used for crystal growth. Here we demonstrate that a triplex-forming oligonucleotide can be used to direct the specific intercalation, and subsequent photo-cross-linking, of 4,5′,8-trimethylpsoralen to single or multiple loci within or between the tiles of the crystal. Cross-linking between the tiles of the crystal improves their thermal stability. Such an approach is likely to facilitate the removal of crystals from their mother liquor and may prove useful for applications that require greater crystal stability.

Original languageEnglish (US)
Pages (from-to)8014-8017
Number of pages4
JournalChemical Communications
Volume52
Issue number51
DOIs
StatePublished - 2016

Fingerprint

DNA
Stabilization
Crystals
Tile
Trioxsalen
Oligonucleotides
Intercalation
Crystallization
Crystal growth
Thermodynamic stability

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys

Cite this

Abdallah, H. O., Ohayon, Y. P., Chandrasekaran, A. R., Sha, R., Fox, K. R., Brown, T., ... Seeman, N. (2016). Stabilisation of self-assembled DNA crystals by triplex-directed photo-cross-linking. Chemical Communications, 52(51), 8014-8017. https://doi.org/10.1039/c6cc03695c

Stabilisation of self-assembled DNA crystals by triplex-directed photo-cross-linking. / Abdallah, Hatem O.; Ohayon, Yoel P.; Chandrasekaran, Arun Richard; Sha, Ruojie; Fox, Keith R.; Brown, Tom; Rusling, David A.; Mao, Chengde; Seeman, Nadrian.

In: Chemical Communications, Vol. 52, No. 51, 2016, p. 8014-8017.

Research output: Contribution to journalArticle

Abdallah, HO, Ohayon, YP, Chandrasekaran, AR, Sha, R, Fox, KR, Brown, T, Rusling, DA, Mao, C & Seeman, N 2016, 'Stabilisation of self-assembled DNA crystals by triplex-directed photo-cross-linking', Chemical Communications, vol. 52, no. 51, pp. 8014-8017. https://doi.org/10.1039/c6cc03695c
Abdallah HO, Ohayon YP, Chandrasekaran AR, Sha R, Fox KR, Brown T et al. Stabilisation of self-assembled DNA crystals by triplex-directed photo-cross-linking. Chemical Communications. 2016;52(51):8014-8017. https://doi.org/10.1039/c6cc03695c
Abdallah, Hatem O. ; Ohayon, Yoel P. ; Chandrasekaran, Arun Richard ; Sha, Ruojie ; Fox, Keith R. ; Brown, Tom ; Rusling, David A. ; Mao, Chengde ; Seeman, Nadrian. / Stabilisation of self-assembled DNA crystals by triplex-directed photo-cross-linking. In: Chemical Communications. 2016 ; Vol. 52, No. 51. pp. 8014-8017.
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