Speech dysfunction in early Parkinson's disease

Celia Stewart, L. Winfield, A. Hunt, S. B. Bressman, S. Fahn, A. Blitzer, M. F. Brin

Research output: Contribution to journalArticle

Abstract

The purpose of this study is to determine if subjects in the early stages of untreated Parkinson's disease (PD) or PD treated with deprenyl alone suffer from motor speech abnormalities. Speech defects are common in advanced PD, including disturbances of respiration, phonation, and articulation. We studied 12 subjects with early PD (Hoehn and Yahr stage ≤ 2, mean duration disease 3.2 years) who were not taking symptomatic therapy and tested them under two conditions: on and off deprenyl. None of the subjects was depressed or demented (Mini Mental Status mean 29.9/30; Hamilton Depression Rating mean 2.7/52). All functioned independently (Schwab and England Activities of Daily Living mean 93.1/100). Acoustic and speech productions were assessed using the DSP Sona-Graph 5500 and an evaluation of dysarthria, All 12 had at least two characteristics of dysarthria on examination, although 8 were not aware of it. Vocal tremor was identified on narrow band spectrogram for four subjects. Deprenyl did not have a consistent effect on speech. Ten subjects had no detectable change in speech on deprenyl, one was worse, and one was improved.

Original languageEnglish (US)
Pages (from-to)562-565
Number of pages4
JournalMovement Disorders
Volume10
Issue number5
DOIs
StatePublished - 1995

Fingerprint

Selegiline
Parkinson Disease
Dysarthria
Speech Acoustics
Phonation
Tremor
Activities of Daily Living
England
Respiration
Depression

Keywords

  • Deprenyl
  • Parkinson's disease
  • Speech dysfunction

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Stewart, C., Winfield, L., Hunt, A., Bressman, S. B., Fahn, S., Blitzer, A., & Brin, M. F. (1995). Speech dysfunction in early Parkinson's disease. Movement Disorders, 10(5), 562-565. https://doi.org/10.1002/mds.870100506

Speech dysfunction in early Parkinson's disease. / Stewart, Celia; Winfield, L.; Hunt, A.; Bressman, S. B.; Fahn, S.; Blitzer, A.; Brin, M. F.

In: Movement Disorders, Vol. 10, No. 5, 1995, p. 562-565.

Research output: Contribution to journalArticle

Stewart, C, Winfield, L, Hunt, A, Bressman, SB, Fahn, S, Blitzer, A & Brin, MF 1995, 'Speech dysfunction in early Parkinson's disease', Movement Disorders, vol. 10, no. 5, pp. 562-565. https://doi.org/10.1002/mds.870100506
Stewart C, Winfield L, Hunt A, Bressman SB, Fahn S, Blitzer A et al. Speech dysfunction in early Parkinson's disease. Movement Disorders. 1995;10(5):562-565. https://doi.org/10.1002/mds.870100506
Stewart, Celia ; Winfield, L. ; Hunt, A. ; Bressman, S. B. ; Fahn, S. ; Blitzer, A. ; Brin, M. F. / Speech dysfunction in early Parkinson's disease. In: Movement Disorders. 1995 ; Vol. 10, No. 5. pp. 562-565.
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