Spectroscopic studies on the interaction between acridine orange and bile salts

E. Chiessi, M. D'Alagni, Gennaro Esposito, E. Giglio

Research output: Contribution to journalArticle

Abstract

The structure of sodium deoxycholate (NaDC) micellar aggregates has been previously reported to be helical, and two helical models have been proposed for the micellar aggregates of sodium taurodeoxycholate (NaTDC). Here we report NMR and UV-VIS studies on the interaction between acridine orange (AO) and NaDC or NaTDC aqueous micellar solutions. AO is known to aggregate in aqueous solutions. The addition of NaDC or NaTDC causes the breaking of the AO aggregates, although the binding geometry of the two bile salts with AO seems to be slightly different. The cationic dye interacts mainly with the C18 and C,9 methyl groups of the bile salt molecules. This result agrees with one of the two NaTDC helical models and with some of its possible aggregates, and confirms again the helical structure attributed to the NaDC micellar aggregates within the limits of the experimental conditions tested by us.

Original languageEnglish (US)
Pages (from-to)453-469
Number of pages17
JournalJournal of Inclusion Phenomena and Molecular Recognition in Chemistry
Volume10
Issue number4
DOIs
StatePublished - Jun 1 1991

Fingerprint

acridine orange
Acridine Orange
bile salts
Bile Acids and Salts
salts
Taurodeoxycholic Acid
deoxycholic acid
interactions
Deoxycholic Acid
sodium
aqueous solutions
dyes
Coloring Agents
Nuclear magnetic resonance
nuclear magnetic resonance
Molecules
Geometry
causes
water
geometry

Keywords

  • acridine orange
  • micelle-probe interaction
  • Sodium deoxycholate and taurodeoxycholate

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Chemistry(all)

Cite this

Spectroscopic studies on the interaction between acridine orange and bile salts. / Chiessi, E.; D'Alagni, M.; Esposito, Gennaro; Giglio, E.

In: Journal of Inclusion Phenomena and Molecular Recognition in Chemistry, Vol. 10, No. 4, 01.06.1991, p. 453-469.

Research output: Contribution to journalArticle

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