Spatiotemporal Self-Organization of Fluctuating Bacterial Colonies

Tobias Grafke, Michael E. Cates, Eric Vanden Eijnden

Research output: Contribution to journalArticle

Abstract

We model an enclosed system of bacteria, whose motility-induced phase separation is coupled to slow population dynamics. Without noise, the system shows both static phase separation and a limit cycle, in which a rising global population causes a dense bacterial colony to form, which then declines by local cell death, before dispersing to reinitiate the cycle. Adding fluctuations, we find that static colonies are now metastable, moving between spatial locations via rare and strongly nonequilibrium pathways, whereas the limit cycle becomes almost periodic such that after each redispersion event the next colony forms in a random location. These results, which hint at some aspects of the biofilm-planktonic life cycle, can be explained by combining tools from large deviation theory with a bifurcation analysis in which the global population density plays the role of control parameter.

Original languageEnglish (US)
Article number188003
JournalPhysical Review Letters
Volume119
Issue number18
DOIs
StatePublished - Nov 3 2017

Fingerprint

cycles
biofilms
locomotion
dispersing
death
bacteria
deviation
causes

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Spatiotemporal Self-Organization of Fluctuating Bacterial Colonies. / Grafke, Tobias; Cates, Michael E.; Vanden Eijnden, Eric.

In: Physical Review Letters, Vol. 119, No. 18, 188003, 03.11.2017.

Research output: Contribution to journalArticle

@article{087d580533124ba2987eeeec70226893,
title = "Spatiotemporal Self-Organization of Fluctuating Bacterial Colonies",
abstract = "We model an enclosed system of bacteria, whose motility-induced phase separation is coupled to slow population dynamics. Without noise, the system shows both static phase separation and a limit cycle, in which a rising global population causes a dense bacterial colony to form, which then declines by local cell death, before dispersing to reinitiate the cycle. Adding fluctuations, we find that static colonies are now metastable, moving between spatial locations via rare and strongly nonequilibrium pathways, whereas the limit cycle becomes almost periodic such that after each redispersion event the next colony forms in a random location. These results, which hint at some aspects of the biofilm-planktonic life cycle, can be explained by combining tools from large deviation theory with a bifurcation analysis in which the global population density plays the role of control parameter.",
author = "Tobias Grafke and Cates, {Michael E.} and {Vanden Eijnden}, Eric",
year = "2017",
month = "11",
day = "3",
doi = "10.1103/PhysRevLett.119.188003",
language = "English (US)",
volume = "119",
journal = "Physical Review Letters",
issn = "0031-9007",
publisher = "American Physical Society",
number = "18",

}

TY - JOUR

T1 - Spatiotemporal Self-Organization of Fluctuating Bacterial Colonies

AU - Grafke, Tobias

AU - Cates, Michael E.

AU - Vanden Eijnden, Eric

PY - 2017/11/3

Y1 - 2017/11/3

N2 - We model an enclosed system of bacteria, whose motility-induced phase separation is coupled to slow population dynamics. Without noise, the system shows both static phase separation and a limit cycle, in which a rising global population causes a dense bacterial colony to form, which then declines by local cell death, before dispersing to reinitiate the cycle. Adding fluctuations, we find that static colonies are now metastable, moving between spatial locations via rare and strongly nonequilibrium pathways, whereas the limit cycle becomes almost periodic such that after each redispersion event the next colony forms in a random location. These results, which hint at some aspects of the biofilm-planktonic life cycle, can be explained by combining tools from large deviation theory with a bifurcation analysis in which the global population density plays the role of control parameter.

AB - We model an enclosed system of bacteria, whose motility-induced phase separation is coupled to slow population dynamics. Without noise, the system shows both static phase separation and a limit cycle, in which a rising global population causes a dense bacterial colony to form, which then declines by local cell death, before dispersing to reinitiate the cycle. Adding fluctuations, we find that static colonies are now metastable, moving between spatial locations via rare and strongly nonequilibrium pathways, whereas the limit cycle becomes almost periodic such that after each redispersion event the next colony forms in a random location. These results, which hint at some aspects of the biofilm-planktonic life cycle, can be explained by combining tools from large deviation theory with a bifurcation analysis in which the global population density plays the role of control parameter.

UR - http://www.scopus.com/inward/record.url?scp=85032787705&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032787705&partnerID=8YFLogxK

U2 - 10.1103/PhysRevLett.119.188003

DO - 10.1103/PhysRevLett.119.188003

M3 - Article

VL - 119

JO - Physical Review Letters

JF - Physical Review Letters

SN - 0031-9007

IS - 18

M1 - 188003

ER -