Spatiotemporal analysis of structural changes of the lamina cribrosa

Charly Girot, Hiroshi Ishikawa, James Fishbaugh, Gadi Wollstein, Joel Schuman, Guido Gerig

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Glaucoma, a progressive and degenerative disease of the optic nerve, is the second leading cause of blindness worldwide. Mechanical deformation of the lamina cribrosa (LC) under high intraocular pressure (IOP) can lead to axonal death of optic nerve fibers. To explore the effect of pressure on the LC, we utilize an experimental setup where longitudinal 3D optical coherence tomography (OCT) images are acquired at different levels of IOP administered via a well-controlled external force. Structural changes are measured via image deformations which map all observed images simultaneously into a common coordinate space. These deformations encode local patterns of structural and volume change across the image sequence, resulting in quantification of the spatiotemporal deformation pattern of the LC due to variation of pressure. We also describe a 3D segmentation algorithm to restrict our deformation analysis separately to the beams or pores of the LC. A single case study demonstrates the potential of the proposed methodology for non-invasive in-vivo analysis of LC dynamics in individual subjects.

    Original languageEnglish (US)
    Title of host publicationFetal, Infant and Ophthalmic Medical Image Analysis - International Workshop, FIFI 2017 and 4th International Workshop, OMIA 2017 Held in Conjunction with MICCAI 2017, Proceedings
    PublisherSpringer Verlag
    Pages185-193
    Number of pages9
    Volume10554 LNCS
    ISBN (Print)9783319675602
    DOIs
    StatePublished - 2017
    EventInternational Workshop on Fetal and Infant Image Analysis, FIFI 2017 and 4th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2017 held in Conjunction with 20th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2017 - Quebec City, Canada
    Duration: Sep 14 2017Sep 14 2017

    Publication series

    NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
    Volume10554 LNCS
    ISSN (Print)0302-9743
    ISSN (Electronic)1611-3349

    Other

    OtherInternational Workshop on Fetal and Infant Image Analysis, FIFI 2017 and 4th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2017 held in Conjunction with 20th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2017
    CountryCanada
    CityQuebec City
    Period9/14/179/14/17

    Fingerprint

    Lamina
    Structural Change
    Nerve
    Optics
    Optical Coherence Tomography
    Optical tomography
    Image Sequence
    Quantification
    Segmentation
    Fiber
    Methodology
    Fibers
    Demonstrate

    Keywords

    • Glaucoma
    • Lamina cribrosa
    • OCT
    • Spatiotemporal analysis

    ASJC Scopus subject areas

    • Theoretical Computer Science
    • Computer Science(all)

    Cite this

    Girot, C., Ishikawa, H., Fishbaugh, J., Wollstein, G., Schuman, J., & Gerig, G. (2017). Spatiotemporal analysis of structural changes of the lamina cribrosa. In Fetal, Infant and Ophthalmic Medical Image Analysis - International Workshop, FIFI 2017 and 4th International Workshop, OMIA 2017 Held in Conjunction with MICCAI 2017, Proceedings (Vol. 10554 LNCS, pp. 185-193). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 10554 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-319-67561-9_21

    Spatiotemporal analysis of structural changes of the lamina cribrosa. / Girot, Charly; Ishikawa, Hiroshi; Fishbaugh, James; Wollstein, Gadi; Schuman, Joel; Gerig, Guido.

    Fetal, Infant and Ophthalmic Medical Image Analysis - International Workshop, FIFI 2017 and 4th International Workshop, OMIA 2017 Held in Conjunction with MICCAI 2017, Proceedings. Vol. 10554 LNCS Springer Verlag, 2017. p. 185-193 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 10554 LNCS).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Girot, C, Ishikawa, H, Fishbaugh, J, Wollstein, G, Schuman, J & Gerig, G 2017, Spatiotemporal analysis of structural changes of the lamina cribrosa. in Fetal, Infant and Ophthalmic Medical Image Analysis - International Workshop, FIFI 2017 and 4th International Workshop, OMIA 2017 Held in Conjunction with MICCAI 2017, Proceedings. vol. 10554 LNCS, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 10554 LNCS, Springer Verlag, pp. 185-193, International Workshop on Fetal and Infant Image Analysis, FIFI 2017 and 4th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2017 held in Conjunction with 20th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2017, Quebec City, Canada, 9/14/17. https://doi.org/10.1007/978-3-319-67561-9_21
    Girot C, Ishikawa H, Fishbaugh J, Wollstein G, Schuman J, Gerig G. Spatiotemporal analysis of structural changes of the lamina cribrosa. In Fetal, Infant and Ophthalmic Medical Image Analysis - International Workshop, FIFI 2017 and 4th International Workshop, OMIA 2017 Held in Conjunction with MICCAI 2017, Proceedings. Vol. 10554 LNCS. Springer Verlag. 2017. p. 185-193. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). https://doi.org/10.1007/978-3-319-67561-9_21
    Girot, Charly ; Ishikawa, Hiroshi ; Fishbaugh, James ; Wollstein, Gadi ; Schuman, Joel ; Gerig, Guido. / Spatiotemporal analysis of structural changes of the lamina cribrosa. Fetal, Infant and Ophthalmic Medical Image Analysis - International Workshop, FIFI 2017 and 4th International Workshop, OMIA 2017 Held in Conjunction with MICCAI 2017, Proceedings. Vol. 10554 LNCS Springer Verlag, 2017. pp. 185-193 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
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