Spatio-temporal analysis of early brain development

Neda Sadeghi, Marcel Prastawa, John H. Gilmore, Weili Lin, Guido Gerig

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Analysis of human brain development is a crucial step for improved understanding of neurodevelopmental disorders. We focus on normal brain development as is observed in the multimodal longitudinal MRI/DTI data of neonates to two years of age. We present a spatio-temporal analysis framework using Gompertz function as a population growth model with three different spatial localization strategies: voxel-based, data driven clustering and atlas driven regional analysis. Growth models from multimodal imaging channels collected at each voxel form feature vectors which are clustered using the Dirichlet Process Mixture Models (DPMM). Clustering thus combines growth information from different modalities to subdivide the image into voxel groups with similar properties. The processing generates spatial maps that highlight the dynamic progression of white matter development. These maps show progression of white matter maturation where primarily, central regions mature earlier compared to the periphery, but where more subtle regional differences in growth can be observed. Atlas based analysis allows a quantitative analysis of a specific anatomical region, whereas data driven clustering identifies regions of similar growth patterns. The combination of these two allows us to investigate growth patterns within an anatomical region. Specifically, analysis of anterior and posterior limb of internal capsule show that there are different growth trajectories within these anatomies, and that it may be useful to divide certain anatomies into subregions with distinctive growth patterns.

    Original languageEnglish (US)
    Title of host publicationConference Record of the 44th Asilomar Conference on Signals, Systems and Computers, Asilomar 2010
    Pages777-781
    Number of pages5
    DOIs
    StatePublished - 2010
    Event44th Asilomar Conference on Signals, Systems and Computers, Asilomar 2010 - Pacific Grove, CA, United States
    Duration: Nov 7 2010Nov 10 2010

    Other

    Other44th Asilomar Conference on Signals, Systems and Computers, Asilomar 2010
    CountryUnited States
    CityPacific Grove, CA
    Period11/7/1011/10/10

    Fingerprint

    Brain
    Magnetic resonance imaging
    Trajectories
    Imaging techniques
    Processing
    Chemical analysis

    Keywords

    • Brain development
    • Diffusion tensor imaging
    • Growth trajectory
    • Longitudinal analysis
    • MRI

    ASJC Scopus subject areas

    • Computer Networks and Communications
    • Signal Processing

    Cite this

    Sadeghi, N., Prastawa, M., Gilmore, J. H., Lin, W., & Gerig, G. (2010). Spatio-temporal analysis of early brain development. In Conference Record of the 44th Asilomar Conference on Signals, Systems and Computers, Asilomar 2010 (pp. 777-781). [5757670] https://doi.org/10.1109/ACSSC.2010.5757670

    Spatio-temporal analysis of early brain development. / Sadeghi, Neda; Prastawa, Marcel; Gilmore, John H.; Lin, Weili; Gerig, Guido.

    Conference Record of the 44th Asilomar Conference on Signals, Systems and Computers, Asilomar 2010. 2010. p. 777-781 5757670.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Sadeghi, N, Prastawa, M, Gilmore, JH, Lin, W & Gerig, G 2010, Spatio-temporal analysis of early brain development. in Conference Record of the 44th Asilomar Conference on Signals, Systems and Computers, Asilomar 2010., 5757670, pp. 777-781, 44th Asilomar Conference on Signals, Systems and Computers, Asilomar 2010, Pacific Grove, CA, United States, 11/7/10. https://doi.org/10.1109/ACSSC.2010.5757670
    Sadeghi N, Prastawa M, Gilmore JH, Lin W, Gerig G. Spatio-temporal analysis of early brain development. In Conference Record of the 44th Asilomar Conference on Signals, Systems and Computers, Asilomar 2010. 2010. p. 777-781. 5757670 https://doi.org/10.1109/ACSSC.2010.5757670
    Sadeghi, Neda ; Prastawa, Marcel ; Gilmore, John H. ; Lin, Weili ; Gerig, Guido. / Spatio-temporal analysis of early brain development. Conference Record of the 44th Asilomar Conference on Signals, Systems and Computers, Asilomar 2010. 2010. pp. 777-781
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