Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy

Gregory A. Dierksen, Maureen E. Skehan, Muhammad A. Khan, Jed Jeng, R. N.Kaveer Nandigam, John A. Becker, Ashok Kumar, Krista L. Neal, Rebecca A. Betensky, Matthew P. Frosch, Jonathan Rosand, Keith A. Johnson, Anand Viswanathan, David H. Salat, Steven M. Greenberg

Research output: Contribution to journalArticle

Abstract

Advanced cerebrovascular β-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2*-weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (p = 0.002) and declined with increasing distance from the microbleed (p < 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition.

Original languageEnglish (US)
Pages (from-to)545-548
Number of pages4
JournalAnnals of Neurology
Volume68
Issue number4
DOIs
StatePublished - Oct 1 2010

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Dierksen, G. A., Skehan, M. E., Khan, M. A., Jeng, J., Nandigam, R. N. K., Becker, J. A., Kumar, A., Neal, K. L., Betensky, R. A., Frosch, M. P., Rosand, J., Johnson, K. A., Viswanathan, A., Salat, D. H., & Greenberg, S. M. (2010). Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy. Annals of Neurology, 68(4), 545-548. https://doi.org/10.1002/ana.22099