Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy

Gregory A. Dierksen, Maureen E. Skehan, Muhammad A. Khan, Jed Jeng, R. N.Kaveer Nandigam, John A. Becker, Ashok Kumar, Krista L. Neal, Rebecca Betensky, Matthew P. Frosch, Jonathan Rosand, Keith A. Johnson, Anand Viswanathan, David H. Salat, Steven M. Greenberg

Research output: Contribution to journalArticle

Abstract

Advanced cerebrovascular β-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2*-weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (p = 0.002) and declined with increasing distance from the microbleed (p < 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition.

Original languageEnglish (US)
Pages (from-to)545-548
Number of pages4
JournalAnnals of Neurology
Volume68
Issue number4
DOIs
StatePublished - Oct 1 2010

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Amyloid Plaques
Cerebral Amyloid Angiopathy
Amyloid
Magnetic Resonance Imaging
Spatial Analysis
Positron-Emission Tomography
Blood Vessels
Amyloid angiopathy
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
Therapeutics

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Dierksen, G. A., Skehan, M. E., Khan, M. A., Jeng, J., Nandigam, R. N. K., Becker, J. A., ... Greenberg, S. M. (2010). Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy. Annals of Neurology, 68(4), 545-548. https://doi.org/10.1002/ana.22099

Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy. / Dierksen, Gregory A.; Skehan, Maureen E.; Khan, Muhammad A.; Jeng, Jed; Nandigam, R. N.Kaveer; Becker, John A.; Kumar, Ashok; Neal, Krista L.; Betensky, Rebecca; Frosch, Matthew P.; Rosand, Jonathan; Johnson, Keith A.; Viswanathan, Anand; Salat, David H.; Greenberg, Steven M.

In: Annals of Neurology, Vol. 68, No. 4, 01.10.2010, p. 545-548.

Research output: Contribution to journalArticle

Dierksen, GA, Skehan, ME, Khan, MA, Jeng, J, Nandigam, RNK, Becker, JA, Kumar, A, Neal, KL, Betensky, R, Frosch, MP, Rosand, J, Johnson, KA, Viswanathan, A, Salat, DH & Greenberg, SM 2010, 'Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy', Annals of Neurology, vol. 68, no. 4, pp. 545-548. https://doi.org/10.1002/ana.22099
Dierksen GA, Skehan ME, Khan MA, Jeng J, Nandigam RNK, Becker JA et al. Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy. Annals of Neurology. 2010 Oct 1;68(4):545-548. https://doi.org/10.1002/ana.22099
Dierksen, Gregory A. ; Skehan, Maureen E. ; Khan, Muhammad A. ; Jeng, Jed ; Nandigam, R. N.Kaveer ; Becker, John A. ; Kumar, Ashok ; Neal, Krista L. ; Betensky, Rebecca ; Frosch, Matthew P. ; Rosand, Jonathan ; Johnson, Keith A. ; Viswanathan, Anand ; Salat, David H. ; Greenberg, Steven M. / Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy. In: Annals of Neurology. 2010 ; Vol. 68, No. 4. pp. 545-548.
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