Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy

Jonathan Rosand, Alona Muzikansky, Ashok Kumar, Jonathan J. Wisco, Eric E. Smith, Rebecca Betensky, Steven M. Greenberg

Research output: Contribution to journalArticle

Abstract

Cerebral amyloid angiopathy (CAA) is a common cause of symptomatic intracerebral hemorrhage (ICH), as well as small asymptomatic hemorrhage in the elderly. We used gradient-echo MRI to analyze spatial distribution of 321 hemorrhages in 59 patients with probable CAA-related ICH. Hemorrhagic lesions were found preferentially in the temporal (ratio of actual to expected hemorrhages = 1.37) and occipital lobes (ratio = 1.45, p < 0.0001). Within individuals, hemorrhages tended to cluster, regardless of lobe (p < 0.0001). Among subjects followed prospectively for recurrence, clustering of new symptomatic and asymptomatic hemorrhages was observed. These data suggest that regional differences within the brain play a role in the development of CAA-related hemorrhage.

Original languageEnglish (US)
Pages (from-to)459-462
Number of pages4
JournalAnnals of Neurology
Volume58
Issue number3
DOIs
StatePublished - Sep 1 2005

Fingerprint

Cerebral Amyloid Angiopathy
Cluster Analysis
Hemorrhage
Cerebral Hemorrhage
Occipital Lobe
Spatial Analysis
Recurrence
Brain

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Rosand, J., Muzikansky, A., Kumar, A., Wisco, J. J., Smith, E. E., Betensky, R., & Greenberg, S. M. (2005). Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy. Annals of Neurology, 58(3), 459-462. https://doi.org/10.1002/ana.20596

Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy. / Rosand, Jonathan; Muzikansky, Alona; Kumar, Ashok; Wisco, Jonathan J.; Smith, Eric E.; Betensky, Rebecca; Greenberg, Steven M.

In: Annals of Neurology, Vol. 58, No. 3, 01.09.2005, p. 459-462.

Research output: Contribution to journalArticle

Rosand, J, Muzikansky, A, Kumar, A, Wisco, JJ, Smith, EE, Betensky, R & Greenberg, SM 2005, 'Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy', Annals of Neurology, vol. 58, no. 3, pp. 459-462. https://doi.org/10.1002/ana.20596
Rosand, Jonathan ; Muzikansky, Alona ; Kumar, Ashok ; Wisco, Jonathan J. ; Smith, Eric E. ; Betensky, Rebecca ; Greenberg, Steven M. / Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy. In: Annals of Neurology. 2005 ; Vol. 58, No. 3. pp. 459-462.
@article{ac7f5df7787242f7a21f027c463f419f,
title = "Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy",
abstract = "Cerebral amyloid angiopathy (CAA) is a common cause of symptomatic intracerebral hemorrhage (ICH), as well as small asymptomatic hemorrhage in the elderly. We used gradient-echo MRI to analyze spatial distribution of 321 hemorrhages in 59 patients with probable CAA-related ICH. Hemorrhagic lesions were found preferentially in the temporal (ratio of actual to expected hemorrhages = 1.37) and occipital lobes (ratio = 1.45, p < 0.0001). Within individuals, hemorrhages tended to cluster, regardless of lobe (p < 0.0001). Among subjects followed prospectively for recurrence, clustering of new symptomatic and asymptomatic hemorrhages was observed. These data suggest that regional differences within the brain play a role in the development of CAA-related hemorrhage.",
author = "Jonathan Rosand and Alona Muzikansky and Ashok Kumar and Wisco, {Jonathan J.} and Smith, {Eric E.} and Rebecca Betensky and Greenberg, {Steven M.}",
year = "2005",
month = "9",
day = "1",
doi = "10.1002/ana.20596",
language = "English (US)",
volume = "58",
pages = "459--462",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy

AU - Rosand, Jonathan

AU - Muzikansky, Alona

AU - Kumar, Ashok

AU - Wisco, Jonathan J.

AU - Smith, Eric E.

AU - Betensky, Rebecca

AU - Greenberg, Steven M.

PY - 2005/9/1

Y1 - 2005/9/1

N2 - Cerebral amyloid angiopathy (CAA) is a common cause of symptomatic intracerebral hemorrhage (ICH), as well as small asymptomatic hemorrhage in the elderly. We used gradient-echo MRI to analyze spatial distribution of 321 hemorrhages in 59 patients with probable CAA-related ICH. Hemorrhagic lesions were found preferentially in the temporal (ratio of actual to expected hemorrhages = 1.37) and occipital lobes (ratio = 1.45, p < 0.0001). Within individuals, hemorrhages tended to cluster, regardless of lobe (p < 0.0001). Among subjects followed prospectively for recurrence, clustering of new symptomatic and asymptomatic hemorrhages was observed. These data suggest that regional differences within the brain play a role in the development of CAA-related hemorrhage.

AB - Cerebral amyloid angiopathy (CAA) is a common cause of symptomatic intracerebral hemorrhage (ICH), as well as small asymptomatic hemorrhage in the elderly. We used gradient-echo MRI to analyze spatial distribution of 321 hemorrhages in 59 patients with probable CAA-related ICH. Hemorrhagic lesions were found preferentially in the temporal (ratio of actual to expected hemorrhages = 1.37) and occipital lobes (ratio = 1.45, p < 0.0001). Within individuals, hemorrhages tended to cluster, regardless of lobe (p < 0.0001). Among subjects followed prospectively for recurrence, clustering of new symptomatic and asymptomatic hemorrhages was observed. These data suggest that regional differences within the brain play a role in the development of CAA-related hemorrhage.

UR - http://www.scopus.com/inward/record.url?scp=24644502161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24644502161&partnerID=8YFLogxK

U2 - 10.1002/ana.20596

DO - 10.1002/ana.20596

M3 - Article

VL - 58

SP - 459

EP - 462

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 3

ER -