Abstract
Increasing evidence suggests that reactive oxygen species (ROS), such as superoxide and hydrogen peroxide, act as necessary signaling molecules in processes underlying cognition. Moreover, ROS have been shown to be necessary in molecular process underlying signal transduction, synaptic plasticity, and memory formation. Research from several laboratories suggests that NADPH oxidase is an important source of superoxide in the brain. Evidence is presented here to show that ROS are in fact important signaling molecules involved in synaptic plasticity and memory formation. Moreover, evidence that the NADPH oxidase complex is a key regulator of ROS generation in synaptic plasticity and memory formation is discussed. Understanding redox signaling in the brain, including the sources and molecular targets of ROS, are important for a full understanding of the signaling pathways that underlie synaptic plasticity and memory. Knowledge of ROS function in the brain also is critical for understanding aging and neurodegenerative diseases of the brain given that several of these disorders, including Alzheimer's disease and Parkinson disease, may be exacerbated by the unregulated generation of ROS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 233-244 |
| Number of pages | 12 |
| Journal | Antioxidants and Redox Signaling |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2007 |
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ASJC Scopus subject areas
- Biochemistry
Cite this
Sources and targets of reactive oxygen species in synaptic plasticity and memory. / Kishida, Kenneth T.; Klann, Eric.
In: Antioxidants and Redox Signaling, Vol. 9, No. 2, 02.2007, p. 233-244.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sources and targets of reactive oxygen species in synaptic plasticity and memory
AU - Kishida, Kenneth T.
AU - Klann, Eric
PY - 2007/2
Y1 - 2007/2
N2 - Increasing evidence suggests that reactive oxygen species (ROS), such as superoxide and hydrogen peroxide, act as necessary signaling molecules in processes underlying cognition. Moreover, ROS have been shown to be necessary in molecular process underlying signal transduction, synaptic plasticity, and memory formation. Research from several laboratories suggests that NADPH oxidase is an important source of superoxide in the brain. Evidence is presented here to show that ROS are in fact important signaling molecules involved in synaptic plasticity and memory formation. Moreover, evidence that the NADPH oxidase complex is a key regulator of ROS generation in synaptic plasticity and memory formation is discussed. Understanding redox signaling in the brain, including the sources and molecular targets of ROS, are important for a full understanding of the signaling pathways that underlie synaptic plasticity and memory. Knowledge of ROS function in the brain also is critical for understanding aging and neurodegenerative diseases of the brain given that several of these disorders, including Alzheimer's disease and Parkinson disease, may be exacerbated by the unregulated generation of ROS.
AB - Increasing evidence suggests that reactive oxygen species (ROS), such as superoxide and hydrogen peroxide, act as necessary signaling molecules in processes underlying cognition. Moreover, ROS have been shown to be necessary in molecular process underlying signal transduction, synaptic plasticity, and memory formation. Research from several laboratories suggests that NADPH oxidase is an important source of superoxide in the brain. Evidence is presented here to show that ROS are in fact important signaling molecules involved in synaptic plasticity and memory formation. Moreover, evidence that the NADPH oxidase complex is a key regulator of ROS generation in synaptic plasticity and memory formation is discussed. Understanding redox signaling in the brain, including the sources and molecular targets of ROS, are important for a full understanding of the signaling pathways that underlie synaptic plasticity and memory. Knowledge of ROS function in the brain also is critical for understanding aging and neurodegenerative diseases of the brain given that several of these disorders, including Alzheimer's disease and Parkinson disease, may be exacerbated by the unregulated generation of ROS.
UR - http://www.scopus.com/inward/record.url?scp=33846241298&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846241298&partnerID=8YFLogxK
U2 - 10.1089/ars.2007.9.233
DO - 10.1089/ars.2007.9.233
M3 - Article
C2 - 17115936
AN - SCOPUS:33846241298
VL - 9
SP - 233
EP - 244
JO - Antioxidants and Redox Signaling
JF - Antioxidants and Redox Signaling
SN - 1523-0864
IS - 2
ER -