Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain

Vitor H. Sousa, Gordon Fishell

    Research output: Contribution to journalReview article

    Abstract

    Morphogens act during development to provide graded spatial information that controls patterning and cell lineage specification in the nervous system. The role of morphogen signaling in instructing the expression of downstream effector transcription factors has been well established. However, a key requirement for morphogen signaling is the existence of functional intracellular machinery able to mediate the appropriate response in target cells. Here we suggest that dynamic changes in the temporal responses to Shh in the developing ventral telencephalon occur through alterations in progenitor competence. We suggest these developmental changes in competence are mediated by a transcriptional mechanism that intrinsically integrates information from the distinct signaling pathways that act to pattern the telencephalic neuroepithelium.

    Original languageEnglish (US)
    Pages (from-to)391-399
    Number of pages9
    JournalCurrent Opinion in Genetics and Development
    Volume20
    Issue number4
    DOIs
    StatePublished - Aug 1 2010

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    Telencephalon
    Prosencephalon
    Mental Competency
    Cell Lineage
    Nervous System
    Transcription Factors

    ASJC Scopus subject areas

    • Genetics
    • Developmental Biology

    Cite this

    Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain. / Sousa, Vitor H.; Fishell, Gordon.

    In: Current Opinion in Genetics and Development, Vol. 20, No. 4, 01.08.2010, p. 391-399.

    Research output: Contribution to journalReview article

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