Soliton-Like States For Opening In Polynucleotide Double Helices

S. W. Englander, N. R. Kallenbach, A. J. Heeger

Research output: Contribution to journalArticle

Abstract

The polar hydrogens of the nucleobases in DNA and synthetic duplexes exchange with solvent hydrogens under conditions in which these molecules are ordered and remote from any denaturation transitions. This behavior of both natural and synthetic polynucleotide duplexes has led to the proposal that ordered double helices contain small amounts of open states, in which bases are unpaired, and that these open states mediate the exchange of otherwise inaccessible hydrogen-bonded protons. In this paper we conclude from analysis of the experimental data that these open configurations can consist of mobile segments on the order of ten base pairs in length. We suggest that these extended open states may be described in terms of solitons, which are now being recognized as Important conformational excitations in polymers and other chain compounds.

Original languageEnglish (US)
Pages (from-to)167
Number of pages1
JournalFerroelectrics
Volume30
Issue number1
DOIs
StatePublished - Oct 1 1980

Fingerprint

polynucleotides
Polynucleotides
Solitons
helices
Hydrogen
solitary waves
hydrogen
Denaturation
biopolymer denaturation
Protons
proposals
Ion exchange
Polymers
DNA
deoxyribonucleic acid
Molecules
protons
polymers
configurations
excitation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Soliton-Like States For Opening In Polynucleotide Double Helices. / Englander, S. W.; Kallenbach, N. R.; Heeger, A. J.

In: Ferroelectrics, Vol. 30, No. 1, 01.10.1980, p. 167.

Research output: Contribution to journalArticle

Englander, SW, Kallenbach, NR & Heeger, AJ 1980, 'Soliton-Like States For Opening In Polynucleotide Double Helices', Ferroelectrics, vol. 30, no. 1, pp. 167. https://doi.org/10.1080/00150198008209510
Englander, S. W. ; Kallenbach, N. R. ; Heeger, A. J. / Soliton-Like States For Opening In Polynucleotide Double Helices. In: Ferroelectrics. 1980 ; Vol. 30, No. 1. pp. 167.
@article{bac925a6ab104bff9c58f8408d2255d1,
title = "Soliton-Like States For Opening In Polynucleotide Double Helices",
abstract = "The polar hydrogens of the nucleobases in DNA and synthetic duplexes exchange with solvent hydrogens under conditions in which these molecules are ordered and remote from any denaturation transitions. This behavior of both natural and synthetic polynucleotide duplexes has led to the proposal that ordered double helices contain small amounts of open states, in which bases are unpaired, and that these open states mediate the exchange of otherwise inaccessible hydrogen-bonded protons. In this paper we conclude from analysis of the experimental data that these open configurations can consist of mobile segments on the order of ten base pairs in length. We suggest that these extended open states may be described in terms of solitons, which are now being recognized as Important conformational excitations in polymers and other chain compounds.",
author = "Englander, {S. W.} and Kallenbach, {N. R.} and Heeger, {A. J.}",
year = "1980",
month = "10",
day = "1",
doi = "10.1080/00150198008209510",
language = "English (US)",
volume = "30",
pages = "167",
journal = "Ferroelectrics",
issn = "0015-0193",
publisher = "Taylor and Francis Ltd.",
number = "1",

}

TY - JOUR

T1 - Soliton-Like States For Opening In Polynucleotide Double Helices

AU - Englander, S. W.

AU - Kallenbach, N. R.

AU - Heeger, A. J.

PY - 1980/10/1

Y1 - 1980/10/1

N2 - The polar hydrogens of the nucleobases in DNA and synthetic duplexes exchange with solvent hydrogens under conditions in which these molecules are ordered and remote from any denaturation transitions. This behavior of both natural and synthetic polynucleotide duplexes has led to the proposal that ordered double helices contain small amounts of open states, in which bases are unpaired, and that these open states mediate the exchange of otherwise inaccessible hydrogen-bonded protons. In this paper we conclude from analysis of the experimental data that these open configurations can consist of mobile segments on the order of ten base pairs in length. We suggest that these extended open states may be described in terms of solitons, which are now being recognized as Important conformational excitations in polymers and other chain compounds.

AB - The polar hydrogens of the nucleobases in DNA and synthetic duplexes exchange with solvent hydrogens under conditions in which these molecules are ordered and remote from any denaturation transitions. This behavior of both natural and synthetic polynucleotide duplexes has led to the proposal that ordered double helices contain small amounts of open states, in which bases are unpaired, and that these open states mediate the exchange of otherwise inaccessible hydrogen-bonded protons. In this paper we conclude from analysis of the experimental data that these open configurations can consist of mobile segments on the order of ten base pairs in length. We suggest that these extended open states may be described in terms of solitons, which are now being recognized as Important conformational excitations in polymers and other chain compounds.

UR - http://www.scopus.com/inward/record.url?scp=84973003300&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84973003300&partnerID=8YFLogxK

U2 - 10.1080/00150198008209510

DO - 10.1080/00150198008209510

M3 - Article

VL - 30

SP - 167

JO - Ferroelectrics

JF - Ferroelectrics

SN - 0015-0193

IS - 1

ER -