Socioeconomic Position, but Not African Genomic Ancestry, Is Associated with Blood Pressure in the Bambui-Epigen (Brazil) Cohort Study of Aging

M. Fernanda Lima-Costa, Juliana Vaz De Mello Mambrini, Maria Lea Correâ Leite, Sérgio Viana Peixoto, Josélia Oliveira Araújo Firmo, Antônio Ignácio De Loyola Filho, Mateus H. Gouveia, Thiago P. Leal, Alexandre Costa Pereira, James MacInko, Eduardo Tarazona-Santos

Research output: Contribution to journalArticle

Abstract

The study objective is to examine the role of African genome origin on baseline and 11-year blood pressure trajectories in community-based ethnoracially admixed older adults in Brazil. Data come from 1272 participants (aged ≥60 years) of the Bambui cohort study of aging during 11 years of follow-up. Outcome measures were systolic blood pressure, diastolic blood pressure, and hypertension control. Potential confounding variables were demographic characteristics, socioeconomic position (schooling and household income), and health indicators (smoking, sedentary lifestyle, high-density lipoprotein cholesterol, waist circumference, diabetes mellitus, and cardiovascular diseases), including antihypertensive drug use. We used 370 539 single-nucleotide polymorphisms to estimate each individual's African, European, and Native American trihybrid ancestry proportions. Median African, European, and Native American ancestry were 9.6%, 84.0%, and 5.3%, respectively. Among those with African ancestry, 59.4% came from East and 40.6% from West Africa. Baseline systolic and diastolic blood pressure, controlled hypertension, and their respective trajectories, were not significantly (P>0.05) associated with level (in quintiles) of African genomic ancestry. Similar results were found for West and East African subcontinental origins. Lower schooling level (

Original languageEnglish (US)
Pages (from-to)349-355
Number of pages7
JournalHypertension
Volume67
Issue number2
DOIs
StatePublished - Feb 1 2016

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Brazil
Cohort Studies
Blood Pressure
North American Indians
African Americans
Hypertension
Sedentary Lifestyle
Western Africa
Confounding Factors (Epidemiology)
Waist Circumference
Epigen
HDL Cholesterol
Antihypertensive Agents
Single Nucleotide Polymorphism
Diabetes Mellitus
Cardiovascular Diseases
Smoking
Demography
Outcome Assessment (Health Care)
Genome

Keywords

  • African continental ancestry group
  • blood pressure
  • cohort studies
  • hypertension

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Lima-Costa, M. F., Mambrini, J. V. D. M., Leite, M. L. C., Peixoto, S. V., Firmo, J. O. A., Loyola Filho, A. I. D., ... Tarazona-Santos, E. (2016). Socioeconomic Position, but Not African Genomic Ancestry, Is Associated with Blood Pressure in the Bambui-Epigen (Brazil) Cohort Study of Aging. Hypertension, 67(2), 349-355. https://doi.org/10.1161/HYPERTENSIONAHA.115.06609

Socioeconomic Position, but Not African Genomic Ancestry, Is Associated with Blood Pressure in the Bambui-Epigen (Brazil) Cohort Study of Aging. / Lima-Costa, M. Fernanda; Mambrini, Juliana Vaz De Mello; Leite, Maria Lea Correâ; Peixoto, Sérgio Viana; Firmo, Josélia Oliveira Araújo; Loyola Filho, Antônio Ignácio De; Gouveia, Mateus H.; Leal, Thiago P.; Pereira, Alexandre Costa; MacInko, James; Tarazona-Santos, Eduardo.

In: Hypertension, Vol. 67, No. 2, 01.02.2016, p. 349-355.

Research output: Contribution to journalArticle

Lima-Costa, MF, Mambrini, JVDM, Leite, MLC, Peixoto, SV, Firmo, JOA, Loyola Filho, AID, Gouveia, MH, Leal, TP, Pereira, AC, MacInko, J & Tarazona-Santos, E 2016, 'Socioeconomic Position, but Not African Genomic Ancestry, Is Associated with Blood Pressure in the Bambui-Epigen (Brazil) Cohort Study of Aging', Hypertension, vol. 67, no. 2, pp. 349-355. https://doi.org/10.1161/HYPERTENSIONAHA.115.06609
Lima-Costa, M. Fernanda ; Mambrini, Juliana Vaz De Mello ; Leite, Maria Lea Correâ ; Peixoto, Sérgio Viana ; Firmo, Josélia Oliveira Araújo ; Loyola Filho, Antônio Ignácio De ; Gouveia, Mateus H. ; Leal, Thiago P. ; Pereira, Alexandre Costa ; MacInko, James ; Tarazona-Santos, Eduardo. / Socioeconomic Position, but Not African Genomic Ancestry, Is Associated with Blood Pressure in the Bambui-Epigen (Brazil) Cohort Study of Aging. In: Hypertension. 2016 ; Vol. 67, No. 2. pp. 349-355.
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