Sociodemographic variation in the oral microbiome

Audrey Renson, Heidi E. Jones, Francesco Beghini, Nicola Segata, Christine P. Zolnik, Mykhaylo Usyk, Thomas U. Moody, Lorna Thorpe, Robert Burk, Levi Waldron, Jennifer B. Dowd

Research output: Contribution to journalArticle

Abstract

Purpose: Variations in the oral microbiome are potentially implicated in social inequalities in oral disease, cancers, and metabolic disease. We describe sociodemographic variation of oral microbiomes in a diverse sample. Methods: We performed 16S rRNA sequencing on mouthwash specimens in a subsample (n = 282)of the 2013–2014 population-based New York City Health and Nutrition Examination Study. We examined differential abundance of 216 operational taxonomic units, and alpha and beta diversity by age, sex, income, education, nativity, and race/ethnicity. For comparison, we examined differential abundance by diet, smoking status, and oral health behaviors. Results: Sixty-nine operational taxonomic units were differentially abundant by any sociodemographic variable (false discovery rate < 0.01), including 27 by race/ethnicity, 21 by family income, 19 by education, 3 by sex. We found 49 differentially abundant by smoking status, 23 by diet, 12 by oral health behaviors. Genera differing for multiple sociodemographic characteristics included Lactobacillus, Prevotella, Porphyromonas, Fusobacterium. Conclusions: We identified oral microbiome variation consistent with health inequalities, more taxa differing by race/ethnicity than diet, and more by SES variables than oral health behaviors. Investigation is warranted into possible mediating effects of the oral microbiome in social disparities in oral and metabolic diseases and cancers.

Original languageEnglish (US)
JournalAnnals of Epidemiology
DOIs
StatePublished - Jan 1 2019

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Microbiota
Health Behavior
Oral Health
Mouth Diseases
Sex Education
Mouth Neoplasms
Metabolic Diseases
Diet
Porphyromonas
Smoking
Fusobacterium
Prevotella
Mouthwashes
Health
Lactobacillus
Population

Keywords

  • Demographics
  • Health disparities
  • Oral microbiome
  • Social epidemiology

ASJC Scopus subject areas

  • Epidemiology

Cite this

Renson, A., Jones, H. E., Beghini, F., Segata, N., Zolnik, C. P., Usyk, M., ... Dowd, J. B. (2019). Sociodemographic variation in the oral microbiome. Annals of Epidemiology. https://doi.org/10.1016/j.annepidem.2019.03.006

Sociodemographic variation in the oral microbiome. / Renson, Audrey; Jones, Heidi E.; Beghini, Francesco; Segata, Nicola; Zolnik, Christine P.; Usyk, Mykhaylo; Moody, Thomas U.; Thorpe, Lorna; Burk, Robert; Waldron, Levi; Dowd, Jennifer B.

In: Annals of Epidemiology, 01.01.2019.

Research output: Contribution to journalArticle

Renson, A, Jones, HE, Beghini, F, Segata, N, Zolnik, CP, Usyk, M, Moody, TU, Thorpe, L, Burk, R, Waldron, L & Dowd, JB 2019, 'Sociodemographic variation in the oral microbiome', Annals of Epidemiology. https://doi.org/10.1016/j.annepidem.2019.03.006
Renson A, Jones HE, Beghini F, Segata N, Zolnik CP, Usyk M et al. Sociodemographic variation in the oral microbiome. Annals of Epidemiology. 2019 Jan 1. https://doi.org/10.1016/j.annepidem.2019.03.006
Renson, Audrey ; Jones, Heidi E. ; Beghini, Francesco ; Segata, Nicola ; Zolnik, Christine P. ; Usyk, Mykhaylo ; Moody, Thomas U. ; Thorpe, Lorna ; Burk, Robert ; Waldron, Levi ; Dowd, Jennifer B. / Sociodemographic variation in the oral microbiome. In: Annals of Epidemiology. 2019.
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