Smoking and drinking in relation to oral cancer and oral epithelial dysplasia

Douglas E. Morse, Walter J. Psoter, Deborah Cleveland, Donald Cohen, Mireseyed Mohit-Tabatabai, Diane L. Kosis, Ellen Eisenberg

Research output: Contribution to journalArticle

Abstract

Objective: Risks associated with smoking and drinking are not necessarily constant over the multistage pathway to oral cancer. We investigated whether smoking and drinking patterns differ for persons with oral cancer (OC) relative to those with oral epithelial dysplasia (OED), a precancerous condition. Methods: Incident cases of OC and OED were interviewed using a questionnaire containing questions on smoking and drinking. Odds ratios (ORs) compared the odds of smoking and drinking among persons with OC relative to OED. Results: No adjusted ORs for smoking achieved statistical significance; however, most were <1.0. The odds of OC relative to OED increased with drinking level; the adjusted OR for 19+ drinks/week was 3.03 (1.56-5.87). Age drinking began and years of drinking were not notably different for OC and OED cases; a higher proportion of OC cases reported discontinuing alcohol for 9+ years before diagnosis. Conclusions: The relationship between smoking and OED was at least as strong as that for smoking and OC, suggesting that smoking may have its greatest impact on oral carcinogenesis prior to malignant transformation. Drinking was more strongly associated with OC than OED, particularly at elevated consumption levels; the role of alcohol does not appear limited to a late-stage effect.

Original languageEnglish (US)
Pages (from-to)919-929
Number of pages11
JournalCancer Causes and Control
Volume18
Issue number9
DOIs
StatePublished - Nov 2007

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Mouth Neoplasms
Drinking
Smoking
Odds Ratio
Alcohols
Precancerous Conditions
Carcinogenesis

Keywords

  • Alcohol drinking
  • Mouth neoplasms
  • Oral cancer
  • Oral dysplasia
  • Tobacco smoking

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Morse, D. E., Psoter, W. J., Cleveland, D., Cohen, D., Mohit-Tabatabai, M., Kosis, D. L., & Eisenberg, E. (2007). Smoking and drinking in relation to oral cancer and oral epithelial dysplasia. Cancer Causes and Control, 18(9), 919-929. https://doi.org/10.1007/s10552-007-9026-4

Smoking and drinking in relation to oral cancer and oral epithelial dysplasia. / Morse, Douglas E.; Psoter, Walter J.; Cleveland, Deborah; Cohen, Donald; Mohit-Tabatabai, Mireseyed; Kosis, Diane L.; Eisenberg, Ellen.

In: Cancer Causes and Control, Vol. 18, No. 9, 11.2007, p. 919-929.

Research output: Contribution to journalArticle

Morse, DE, Psoter, WJ, Cleveland, D, Cohen, D, Mohit-Tabatabai, M, Kosis, DL & Eisenberg, E 2007, 'Smoking and drinking in relation to oral cancer and oral epithelial dysplasia', Cancer Causes and Control, vol. 18, no. 9, pp. 919-929. https://doi.org/10.1007/s10552-007-9026-4
Morse DE, Psoter WJ, Cleveland D, Cohen D, Mohit-Tabatabai M, Kosis DL et al. Smoking and drinking in relation to oral cancer and oral epithelial dysplasia. Cancer Causes and Control. 2007 Nov;18(9):919-929. https://doi.org/10.1007/s10552-007-9026-4
Morse, Douglas E. ; Psoter, Walter J. ; Cleveland, Deborah ; Cohen, Donald ; Mohit-Tabatabai, Mireseyed ; Kosis, Diane L. ; Eisenberg, Ellen. / Smoking and drinking in relation to oral cancer and oral epithelial dysplasia. In: Cancer Causes and Control. 2007 ; Vol. 18, No. 9. pp. 919-929.
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