Sleep continuity measured by survival curve analysis

Robert G. Norman, Marc A. Scott, Indu Ayappa, Joyce A. Walsleben, David M. Rapoport

Research output: Contribution to journalArticle

Abstract

Study Objectives: To develop and demonstrate the utility of measures of sleep continuity based on survival analysis techniques. Design: Retrospective. Setting: University sleep laboratory. Patients: Anonymous nocturnal polysomnograms from 10 normal subjects, 10 subjects with mild sleep disordered breathing (SDB) (apnea-hypopnea index [AHI], 15-30/hr), and 10 subjects with moderate/severe SDB (AHI > 30/hr). Interventions: N/A Measurements and Results: Hypnograms were analyzed to measure the lengths of episodes of contiguous sleep and processed using several common survival analysis techniques. Using separate survival curves for each group to describe the durations of continuous epochs of sleep (sleep run lengths), statistically significant differences were found between all groups (p<.001) as well as between the normal and mild SDB groups (p<.001), suggesting differences in the stability of sleep. Using survival regression techniques applied separately to each subject, statistically significant differences were found among all three groups (p<.001) and, more importantly, between the normal and mild SDB groups (p<.005). Similarly, estimation of sleep continuity based on the pooled sleep run data for each group also showed statistically significant differences (normal vs mild, p<.001; Normal vs moderate/severe, p<.001). In addition, the latter technique showed that changes in the "stability" of sleep could be demonstrated as runs progressed. Conclusion: Survival curve analysis of the lengths of runs of contiguous sleep provides a potentially useful method of quantifying sleep continuity. The results suggest that sleep becomes more stable as sleep progresses in normal subjects and those with mild SDB and less stable in subjects with moderate/severe SDB.

Original languageEnglish (US)
Pages (from-to)1625-1631
Number of pages7
JournalSleep
Volume29
Issue number12
StatePublished - Dec 1 2006

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Survival Analysis
Sleep
Sleep Apnea Syndromes
Apnea
Survival

Keywords

  • Sleep continuity
  • Sleep disordered breathing
  • Sleep fragmentation
  • Sleep runs
  • Survival analysis

ASJC Scopus subject areas

  • Physiology

Cite this

Norman, R. G., Scott, M. A., Ayappa, I., Walsleben, J. A., & Rapoport, D. M. (2006). Sleep continuity measured by survival curve analysis. Sleep, 29(12), 1625-1631.

Sleep continuity measured by survival curve analysis. / Norman, Robert G.; Scott, Marc A.; Ayappa, Indu; Walsleben, Joyce A.; Rapoport, David M.

In: Sleep, Vol. 29, No. 12, 01.12.2006, p. 1625-1631.

Research output: Contribution to journalArticle

Norman, RG, Scott, MA, Ayappa, I, Walsleben, JA & Rapoport, DM 2006, 'Sleep continuity measured by survival curve analysis', Sleep, vol. 29, no. 12, pp. 1625-1631.
Norman RG, Scott MA, Ayappa I, Walsleben JA, Rapoport DM. Sleep continuity measured by survival curve analysis. Sleep. 2006 Dec 1;29(12):1625-1631.
Norman, Robert G. ; Scott, Marc A. ; Ayappa, Indu ; Walsleben, Joyce A. ; Rapoport, David M. / Sleep continuity measured by survival curve analysis. In: Sleep. 2006 ; Vol. 29, No. 12. pp. 1625-1631.
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