Sirtuin 1 is a negative regulator of parathyroid hormone stimulation of matrix metalloproteinase 13 expression in osteoblastic cells: Role of sirtuin 1 in the action of PTH on osteoblasts

Yurong Fei, Emi Shimizu, Michael W. McBurney, Nicola C. Partridge

Research output: Contribution to journalArticle

Abstract

Background: Parathyroid hormone (PTH) stimulates MMP13 in osteoblasts. Results: Sirtuin 1 (SIRT1) activation suppresses PTH stimulation of Mmp13 expression, and this process is mediated by the AP-1 complex. Conclusion: SIRT1 is a novel suppressor of PTH stimulation of MMP13 expression. Significance: Activation of SIRT1 and suppression of MMP13may prolong the anabolic bone-forming period of PTH treatment in osteoporotic patients.

Original languageEnglish (US)
Pages (from-to)8373-8382
Number of pages10
JournalJournal of Biological Chemistry
Volume290
Issue number13
DOIs
StatePublished - Mar 27 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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