Single neurons in the monkey hippocampus and learning of new associations

Sylvia Wirth, Marianna Yanike, Loren M. Frank, Anne C. Smith, Emery N. Brown, Wendy Suzuki

Research output: Contribution to journalArticle

Abstract

The medial temporal lobe is crucial for the ability to learn and retain new declarative memories. This form of memory includes the ability to quickly establish novel associations between unrelated items. To better understand the patterns of neural activity during associative memory formation, we recorded the activity of hippocampal neurons of macaque monkeys as they learned new associations. Hippocampal neurons signaled learning by changing their stimulus-selective response properties. This change in the pattern of selective neural activity occurred before, at the same time as, or after learning, which suggests that these neurons are involved in the initial formation of new associative memories.

Original languageEnglish (US)
Pages (from-to)1578-1581
Number of pages4
JournalScience
Volume300
Issue number5625
DOIs
StatePublished - Jun 6 2003

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Association Learning
Haplorhini
Hippocampus
Neurons
Aptitude
Learning
Macaca
Temporal Lobe

ASJC Scopus subject areas

  • General

Cite this

Wirth, S., Yanike, M., Frank, L. M., Smith, A. C., Brown, E. N., & Suzuki, W. (2003). Single neurons in the monkey hippocampus and learning of new associations. Science, 300(5625), 1578-1581. https://doi.org/10.1126/science.1084324

Single neurons in the monkey hippocampus and learning of new associations. / Wirth, Sylvia; Yanike, Marianna; Frank, Loren M.; Smith, Anne C.; Brown, Emery N.; Suzuki, Wendy.

In: Science, Vol. 300, No. 5625, 06.06.2003, p. 1578-1581.

Research output: Contribution to journalArticle

Wirth, S, Yanike, M, Frank, LM, Smith, AC, Brown, EN & Suzuki, W 2003, 'Single neurons in the monkey hippocampus and learning of new associations', Science, vol. 300, no. 5625, pp. 1578-1581. https://doi.org/10.1126/science.1084324
Wirth, Sylvia ; Yanike, Marianna ; Frank, Loren M. ; Smith, Anne C. ; Brown, Emery N. ; Suzuki, Wendy. / Single neurons in the monkey hippocampus and learning of new associations. In: Science. 2003 ; Vol. 300, No. 5625. pp. 1578-1581.
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