Simulated effects of marathon training on bone density, remodeling, and microdamage accumulation of the femur

Scott J. Hazelwood, Alesha B. Castillo

    Research output: Contribution to journalArticle


    Stress fractures are mechanically induced injuries resulting from fatigue damage to bone due to repetitive loading and are common injuries occurring in runners. In this study, we used computer simulations of marathon training programs to examine the effects of endurance running on femoral density, remodeling, and microdamage accumulation. Simulated remodeling activity increased in the femoral neck and proximal cortex and predicted microdamage increased in all regions examined after 16 weeks for each program. Daily running for three years produced more microdamage than the advanced training schedule over the same time period. Areas of high remodeling and damage corresponded to clinically observed locations of femoral stress fractures, indicating that the simulation may be useful in designing training programs to reduce fracture risk.

    Original languageEnglish (US)
    Pages (from-to)1057-1064
    Number of pages8
    JournalInternational Journal of Fatigue
    Issue number6
    StatePublished - Jun 1 2007



    • Bone remodeling
    • Computer simulation
    • Damage
    • Fatigue
    • Stress fracture

    ASJC Scopus subject areas

    • Modeling and Simulation
    • Materials Science(all)
    • Mechanics of Materials
    • Mechanical Engineering
    • Industrial and Manufacturing Engineering

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