Simple quantitative model for the reversible association of DNA coated colloids

Rémi Dreyfus, Mirjam E. Leunissen, Roujie Sha, Alexei V. Tkachenko, Nadrian C. Seeman, David J. Pine, Paul M. Chaikin

Research output: Contribution to journalArticle

Abstract

We investigate the reversible association of micrometer-sized colloids coated with complementary single-stranded DNA "sticky ends" as a function of the temperature and the sticky end coverage. We find that even a qualitative description of the dissociation transition curves requires the inclusion of an entropic cost. We develop a simple general model for this cost in terms of the configurational entropy loss due to binding and confinement of the tethered DNA between neighboring particles. With this easy-to-use model, we demonstrate for different kinds of DNA constructs quantitative control over the dissociation temperature and the sharpness of the dissociation curve, both essential properties for complex self-assembly processes.

Original languageEnglish (US)
Article number048301
JournalPhysical Review Letters
Volume102
Issue number4
DOIs
StatePublished - Jan 26 2009

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colloids
deoxyribonucleic acid
dissociation
costs
sharpness
curves
self assembly
micrometers
inclusions
entropy
temperature

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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Simple quantitative model for the reversible association of DNA coated colloids. / Dreyfus, Rémi; Leunissen, Mirjam E.; Sha, Roujie; Tkachenko, Alexei V.; Seeman, Nadrian C.; Pine, David J.; Chaikin, Paul M.

In: Physical Review Letters, Vol. 102, No. 4, 048301, 26.01.2009.

Research output: Contribution to journalArticle

Dreyfus, Rémi ; Leunissen, Mirjam E. ; Sha, Roujie ; Tkachenko, Alexei V. ; Seeman, Nadrian C. ; Pine, David J. ; Chaikin, Paul M. / Simple quantitative model for the reversible association of DNA coated colloids. In: Physical Review Letters. 2009 ; Vol. 102, No. 4.
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