Signal transduction in the early Drosophila embryo: when genetics meets biochemistry

Norbert Perrimon, Claude Desplan

Research output: Contribution to journalArticle

Abstract

An elegant combination of genetic and biochemical approaches has been used to investigate a variety of signal transduction pathways in developmental processes. Here, we describe the 'terminal' signaling system in the Drosophila embryo, which is responsible for pattern formation in the polar regions of the embryo. This pathway involves a membrane-bound receptor tyrosine kinase (RTK) that is similar to other Drosophila RTKs, such as sevenless, and the mammalian RTKs, such as the epidermal growth factor or platelet-derived growth factor receptors.

Original languageEnglish (US)
Pages (from-to)509-513
Number of pages5
JournalTrends in Biochemical Sciences
Volume19
Issue number11
DOIs
StatePublished - Nov 1994

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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