Side chain elongation causes a change from enthalpy driven to entropy driven binding in the molecular recognition of tetraanionic peptides

Xavier Salvatella, Mark W. Peczuh, Margarida Gairí, Rishi K. Jain, Jorge Sánchez-Quesada, Javier De Mendoza, Andrew D. Hamilton, Ernest Giralt

Research output: Contribution to journalArticle


In binding to tetraguanidinium compounds, the average side chain length of tetraanionic peptides determines the thermodynamics of binding, the degree of helix induction and the rigidity of the complex formed.

Original languageEnglish (US)
Pages (from-to)1399-1400
Number of pages2
JournalChemical Communications
Issue number15
StatePublished - Aug 7 2000


ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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