Short sleep duration as a risk factor for hypertension: Analyses of the first National Health and Nutrition Examination Survey

James E. Gangwisch, Steven B. Heymsfield, Bernadette Boden-Albala, Ruud M. Buijs, Felix Kreier, Thomas G. Pickering, Andrew G. Rundle, Gary K. Zammit, Dolores Malaspina

Research output: Contribution to journalArticle

Abstract

Depriving healthy subjects of sleep has been shown to acutely increase blood pressure and sympathetic nervous system activity. Prolonged short sleep durations could lead to hypertension through extended exposure to raised 24-hour blood pressure and heart rate, elevated sympathetic nervous system activity, and increased salt retention. Such forces could lead to structural adaptations and the entrainment of the cardiovascular system to operate at an elevated pressure equilibrium. Sleep disorders are associated with cardiovascular disease, but we are not aware of any published prospective population studies that have shown a link between short sleep duration and the incidence of hypertension in subjects without apparent sleep disorders. We assessed whether short sleep duration would increase the risk for hypertension incidence by conducting longitudinal analyses of the first National Health and Nutrition Examination Survey (n=4810) using Cox proportional hazards models and controlling for covariates. Hypertension incidence (n=647) was determined by physician diagnosis, hospital record, or cause of death over the 8- to 10-year follow-up period between 1982 and 1992. Sleep durations of ≤5 hours per night were associated with a significantly increased risk of hypertension (hazard ratio, 2.10; 95% CI, 1.58 to 2.79) in subjects between the ages of 32 and 59 years, and controlling for the potential confounding variables only partially attenuated this relationship. The increased risk continued to be significant after controlling for obesity and diabetes, which was consistent with the hypothesis that these variables would act as partial mediators. Short sleep duration could, therefore, be a significant risk factor for hypertension.

Original languageEnglish (US)
Pages (from-to)833-839
Number of pages7
JournalHypertension
Volume47
Issue number5
DOIs
StatePublished - May 2006

Fingerprint

Nutrition Surveys
Statistical Factor Analysis
Sleep
Hypertension
Sympathetic Nervous System
Incidence
Blood Pressure
Confounding Factors (Epidemiology)
Hospital Records
Cardiovascular System
Proportional Hazards Models
Cause of Death
Healthy Volunteers
Cardiovascular Diseases
Obesity
Salts
Heart Rate
Prospective Studies
Physicians
Pressure

Keywords

  • Circadian rhythm
  • Diabetes mellitus
  • Essential
  • Hypertension
  • Obesity
  • Sleep

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Short sleep duration as a risk factor for hypertension : Analyses of the first National Health and Nutrition Examination Survey. / Gangwisch, James E.; Heymsfield, Steven B.; Boden-Albala, Bernadette; Buijs, Ruud M.; Kreier, Felix; Pickering, Thomas G.; Rundle, Andrew G.; Zammit, Gary K.; Malaspina, Dolores.

In: Hypertension, Vol. 47, No. 5, 05.2006, p. 833-839.

Research output: Contribution to journalArticle

Gangwisch, JE, Heymsfield, SB, Boden-Albala, B, Buijs, RM, Kreier, F, Pickering, TG, Rundle, AG, Zammit, GK & Malaspina, D 2006, 'Short sleep duration as a risk factor for hypertension: Analyses of the first National Health and Nutrition Examination Survey', Hypertension, vol. 47, no. 5, pp. 833-839. https://doi.org/10.1161/01.HYP.0000217362.34748.e0
Gangwisch, James E. ; Heymsfield, Steven B. ; Boden-Albala, Bernadette ; Buijs, Ruud M. ; Kreier, Felix ; Pickering, Thomas G. ; Rundle, Andrew G. ; Zammit, Gary K. ; Malaspina, Dolores. / Short sleep duration as a risk factor for hypertension : Analyses of the first National Health and Nutrition Examination Survey. In: Hypertension. 2006 ; Vol. 47, No. 5. pp. 833-839.
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