Short chain fatty acids produced by anaerobic bacteria inhibit adhesion and proliferation of periodontal ligament fibroblasts.

C. Eftimiadi, S. Valente, S. Mangiante, P. E. Mangiante, Richard Niederman

Research output: Contribution to journalArticle

Abstract

Short chain fatty acids (SCFA) are metabolic by-products of anaerobic bacteria present in the periodontal pocket. We examined the effect of SCFA on cultured human periodontal ligament fibroblasts (PDLF). PDLF were challenged with propionate, butyrate and succinate. A dose dependent inhibition of fibroblast adhesion and proliferation was observed. These results indicate that SCFA present in the periodontal pockets could interfere with periodontal wound healing and repair in patients affected by periodontal infections.

Original languageEnglish (US)
Pages (from-to)481-485
Number of pages5
JournalMinerva Stomatologica
Volume42
Issue number11-12
StatePublished - Nov 1993

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Periodontal Ligament
Anaerobic Bacteria
Volatile Fatty Acids
Periodontal Pocket
Fibroblasts
Butyrates
Propionates
Succinic Acid
Wound Healing
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Short chain fatty acids produced by anaerobic bacteria inhibit adhesion and proliferation of periodontal ligament fibroblasts. / Eftimiadi, C.; Valente, S.; Mangiante, S.; Mangiante, P. E.; Niederman, Richard.

In: Minerva Stomatologica, Vol. 42, No. 11-12, 11.1993, p. 481-485.

Research output: Contribution to journalArticle

Eftimiadi, C. ; Valente, S. ; Mangiante, S. ; Mangiante, P. E. ; Niederman, Richard. / Short chain fatty acids produced by anaerobic bacteria inhibit adhesion and proliferation of periodontal ligament fibroblasts. In: Minerva Stomatologica. 1993 ; Vol. 42, No. 11-12. pp. 481-485.
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