Sex differences in susceptibility to viral infection of the central nervous system

Maria Barna, Takashi Komatsu, Zhengbiao Bi, Carol S. Reiss

Research output: Contribution to journalArticle

Abstract

We have characterized striking differences in recovery of male and female BALB/c and BALB/c-H-2(dm2) (dm2) mice from an experimental neurotropic viral infection of the central nervous system (CNS). Following intranasal inoculation of vesicular stomatitis virus (VSV), assays of tissue homogenates from female mice produced lower viral titers. There was also a significant reduction in the spread of virus from the rostral to caudal end of the brain in female mice. Enhanced recovery by female mice of both strains in response to this viral insult correlates with increased levels of Nitric Oxide Synthase (NOS) types I, II, and III expression, an increased prevalence of reactive astrocytes, earlier and enhanced levels of expression of Major Histocompatabilty Complex (MHC) class II molecules on astrocytes, endothelial and microglial cells, and increased T cell infiltration in the female BALB/c mouse. Taken together, these findings document sexual dimorphism in CNS immunity, and may provide an understanding of some of the mechanisms underlying many sex-biased diseases.

Original languageEnglish (US)
Pages (from-to)31-39
Number of pages9
JournalJournal of Neuroimmunology
Volume67
Issue number1
DOIs
StatePublished - Jun 1996

Fingerprint

Central Nervous System Viral Diseases
Sex Characteristics
Astrocytes
Viruses
Nitric Oxide Synthase Type I
Vesicular Stomatitis
Nitric Oxide Synthase Type III
Nitric Oxide Synthase Type II
Immunity
Central Nervous System
Endothelial Cells
T-Lymphocytes
Brain

Keywords

  • BALB/c mice
  • Central nervous system immunity
  • Disease susceptibility
  • Neutropic viral infection
  • Sex-bias
  • Sexual dimorphism
  • T cell

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Sex differences in susceptibility to viral infection of the central nervous system. / Barna, Maria; Komatsu, Takashi; Bi, Zhengbiao; Reiss, Carol S.

In: Journal of Neuroimmunology, Vol. 67, No. 1, 06.1996, p. 31-39.

Research output: Contribution to journalArticle

Barna, Maria ; Komatsu, Takashi ; Bi, Zhengbiao ; Reiss, Carol S. / Sex differences in susceptibility to viral infection of the central nervous system. In: Journal of Neuroimmunology. 1996 ; Vol. 67, No. 1. pp. 31-39.
@article{e8161c804cd74a3998e6a324854bbe22,
title = "Sex differences in susceptibility to viral infection of the central nervous system",
abstract = "We have characterized striking differences in recovery of male and female BALB/c and BALB/c-H-2(dm2) (dm2) mice from an experimental neurotropic viral infection of the central nervous system (CNS). Following intranasal inoculation of vesicular stomatitis virus (VSV), assays of tissue homogenates from female mice produced lower viral titers. There was also a significant reduction in the spread of virus from the rostral to caudal end of the brain in female mice. Enhanced recovery by female mice of both strains in response to this viral insult correlates with increased levels of Nitric Oxide Synthase (NOS) types I, II, and III expression, an increased prevalence of reactive astrocytes, earlier and enhanced levels of expression of Major Histocompatabilty Complex (MHC) class II molecules on astrocytes, endothelial and microglial cells, and increased T cell infiltration in the female BALB/c mouse. Taken together, these findings document sexual dimorphism in CNS immunity, and may provide an understanding of some of the mechanisms underlying many sex-biased diseases.",
keywords = "BALB/c mice, Central nervous system immunity, Disease susceptibility, Neutropic viral infection, Sex-bias, Sexual dimorphism, T cell",
author = "Maria Barna and Takashi Komatsu and Zhengbiao Bi and Reiss, {Carol S.}",
year = "1996",
month = "6",
doi = "10.1016/S0165-5728(96)00022-7",
language = "English (US)",
volume = "67",
pages = "31--39",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Sex differences in susceptibility to viral infection of the central nervous system

AU - Barna, Maria

AU - Komatsu, Takashi

AU - Bi, Zhengbiao

AU - Reiss, Carol S.

PY - 1996/6

Y1 - 1996/6

N2 - We have characterized striking differences in recovery of male and female BALB/c and BALB/c-H-2(dm2) (dm2) mice from an experimental neurotropic viral infection of the central nervous system (CNS). Following intranasal inoculation of vesicular stomatitis virus (VSV), assays of tissue homogenates from female mice produced lower viral titers. There was also a significant reduction in the spread of virus from the rostral to caudal end of the brain in female mice. Enhanced recovery by female mice of both strains in response to this viral insult correlates with increased levels of Nitric Oxide Synthase (NOS) types I, II, and III expression, an increased prevalence of reactive astrocytes, earlier and enhanced levels of expression of Major Histocompatabilty Complex (MHC) class II molecules on astrocytes, endothelial and microglial cells, and increased T cell infiltration in the female BALB/c mouse. Taken together, these findings document sexual dimorphism in CNS immunity, and may provide an understanding of some of the mechanisms underlying many sex-biased diseases.

AB - We have characterized striking differences in recovery of male and female BALB/c and BALB/c-H-2(dm2) (dm2) mice from an experimental neurotropic viral infection of the central nervous system (CNS). Following intranasal inoculation of vesicular stomatitis virus (VSV), assays of tissue homogenates from female mice produced lower viral titers. There was also a significant reduction in the spread of virus from the rostral to caudal end of the brain in female mice. Enhanced recovery by female mice of both strains in response to this viral insult correlates with increased levels of Nitric Oxide Synthase (NOS) types I, II, and III expression, an increased prevalence of reactive astrocytes, earlier and enhanced levels of expression of Major Histocompatabilty Complex (MHC) class II molecules on astrocytes, endothelial and microglial cells, and increased T cell infiltration in the female BALB/c mouse. Taken together, these findings document sexual dimorphism in CNS immunity, and may provide an understanding of some of the mechanisms underlying many sex-biased diseases.

KW - BALB/c mice

KW - Central nervous system immunity

KW - Disease susceptibility

KW - Neutropic viral infection

KW - Sex-bias

KW - Sexual dimorphism

KW - T cell

UR - http://www.scopus.com/inward/record.url?scp=0030176199&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030176199&partnerID=8YFLogxK

U2 - 10.1016/S0165-5728(96)00022-7

DO - 10.1016/S0165-5728(96)00022-7

M3 - Article

VL - 67

SP - 31

EP - 39

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1

ER -