Serum taurine and stroke risk in women: A prospective, nested case-control study

Fen Wu, Karen L. Koenig, Anne Zeleniuch-Jacquotte, Saran Jonas, Yelena Afanasyeva, Oktawia P. Wójcik, Max Costa, Yu Chen

Research output: Contribution to journalArticle

Abstract

Background: Taurine (2-aminoethanesulfonic acid), a conditionally essential sulfur-containing amino acid, is mainly obtained from diet in humans. Experimental studies have shown that taurine's main biological actions include bile salt conjugation, blood pressure regulation, antioxidation, and anti-inflammation. Methods: We conducted a prospective case-control study nested in the New York University Women's Health Study, a cohort study involving 14,274 women enrolled since 1985. Taurine was measured in pre-diagnostic serum samples of 241 stroke cases and 479 matched controls. Results: There was no statistically significant association between serum taurine and stroke risk in the overall study population. The adjusted ORs for stroke were 1.0 (reference), 0.87 (95% CI, 0.59-1.28), and 1.03 (95% CI, 0.69-1.54) in increasing tertiles of taurine (64.3-126.6, 126.7-152.9, and 153.0-308.5 nmol/mL, respectively). A significant inverse association between serum taurine and stroke risk was observed among never smokers, with an adjusted OR of 0.66 (95% CI, 0.37-1.18) and 0.50 (95% CI, 0.26-0.94) for the second and third tertile, respectively (p for trend = 0.01), but not among past or current smokers (p for interaction < 0.01). Conclusions: We observed no overall association between serum taurine and stroke risk, although a protective effect was observed in never smokers, which requires further investigation. Taurine, Stroke, Epidemiology, Prospective, Case-control study, NYUWHS.

Original languageEnglish (US)
Article numbere0149348
JournalPLoS One
Volume11
Issue number2
DOIs
StatePublished - Feb 1 2016

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Taurine
taurine
case-control studies
stroke
Case-Control Studies
Stroke
Serum
Pressure regulation
Sulfur Amino Acids
women's health
Epidemiology
Essential Amino Acids
bile salts
Blood pressure
Women's Health
Nutrition
Bile Acids and Salts
cohort studies
Sulfur
blood pressure

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Wu, F., Koenig, K. L., Zeleniuch-Jacquotte, A., Jonas, S., Afanasyeva, Y., Wójcik, O. P., ... Chen, Y. (2016). Serum taurine and stroke risk in women: A prospective, nested case-control study. PLoS One, 11(2), [e0149348]. https://doi.org/10.1371/journal.pone.0149348

Serum taurine and stroke risk in women : A prospective, nested case-control study. / Wu, Fen; Koenig, Karen L.; Zeleniuch-Jacquotte, Anne; Jonas, Saran; Afanasyeva, Yelena; Wójcik, Oktawia P.; Costa, Max; Chen, Yu.

In: PLoS One, Vol. 11, No. 2, e0149348, 01.02.2016.

Research output: Contribution to journalArticle

Wu, F, Koenig, KL, Zeleniuch-Jacquotte, A, Jonas, S, Afanasyeva, Y, Wójcik, OP, Costa, M & Chen, Y 2016, 'Serum taurine and stroke risk in women: A prospective, nested case-control study', PLoS One, vol. 11, no. 2, e0149348. https://doi.org/10.1371/journal.pone.0149348
Wu F, Koenig KL, Zeleniuch-Jacquotte A, Jonas S, Afanasyeva Y, Wójcik OP et al. Serum taurine and stroke risk in women: A prospective, nested case-control study. PLoS One. 2016 Feb 1;11(2). e0149348. https://doi.org/10.1371/journal.pone.0149348
Wu, Fen ; Koenig, Karen L. ; Zeleniuch-Jacquotte, Anne ; Jonas, Saran ; Afanasyeva, Yelena ; Wójcik, Oktawia P. ; Costa, Max ; Chen, Yu. / Serum taurine and stroke risk in women : A prospective, nested case-control study. In: PLoS One. 2016 ; Vol. 11, No. 2.
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abstract = "Background: Taurine (2-aminoethanesulfonic acid), a conditionally essential sulfur-containing amino acid, is mainly obtained from diet in humans. Experimental studies have shown that taurine's main biological actions include bile salt conjugation, blood pressure regulation, antioxidation, and anti-inflammation. Methods: We conducted a prospective case-control study nested in the New York University Women's Health Study, a cohort study involving 14,274 women enrolled since 1985. Taurine was measured in pre-diagnostic serum samples of 241 stroke cases and 479 matched controls. Results: There was no statistically significant association between serum taurine and stroke risk in the overall study population. The adjusted ORs for stroke were 1.0 (reference), 0.87 (95{\%} CI, 0.59-1.28), and 1.03 (95{\%} CI, 0.69-1.54) in increasing tertiles of taurine (64.3-126.6, 126.7-152.9, and 153.0-308.5 nmol/mL, respectively). A significant inverse association between serum taurine and stroke risk was observed among never smokers, with an adjusted OR of 0.66 (95{\%} CI, 0.37-1.18) and 0.50 (95{\%} CI, 0.26-0.94) for the second and third tertile, respectively (p for trend = 0.01), but not among past or current smokers (p for interaction < 0.01). Conclusions: We observed no overall association between serum taurine and stroke risk, although a protective effect was observed in never smokers, which requires further investigation. Taurine, Stroke, Epidemiology, Prospective, Case-control study, NYUWHS.",
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