Serotonin1A Receptors at the Axon Initial Segment of Prefrontal Pyramidal Neurons in Schizophrenia

Dianne A. Cruz, Stephen M. Eggan, Efrain C. Azmitia, David A. Lewis

Research output: Contribution to journalArticle

Abstract

Objective: Inhibition mediated by γ-aminobutyric acid at the axon initial segment of pyramidal neurons appears to be altered in the prefrontal cortex in schizophrenia. This study examined the densities and laminar distribution of axon initial segments labeled with an antibody against the serotonin1A (5-HT1A) receptor, which also mediates inhibitory regulation of pyramidal neurons, in subjects with schizophrenia. Method: The densities and laminar distribution of axon initial segments with 5-HT1A-like immunoreactivity were assessed in postmortem tissue from the prefrontal cortex (Brodmann's area 46) of 14 matched triads of subjects with schizophrenia, subjects with major depressive disorder, and comparison subjects with no psychiatric disorder. Results: The relative densities of the labeled axon initial segment in both the superficial and the deep cortical layers did not differ across the three subject groups. Conclusions: The findings do not support a role for altered serotonin transmission by means of the 5-HT1A receptor in dysfunction of prefrontal cortex pyramidal neurons in schizophrenia.

Original languageEnglish (US)
Pages (from-to)739-742
Number of pages4
JournalAmerican Journal of Psychiatry
Volume161
Issue number4
DOIs
StatePublished - Apr 2004

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Pyramidal Cells
Schizophrenia
Prefrontal Cortex
Receptor, Serotonin, 5-HT1A
Aminobutyrates
Specific Gravity
Major Depressive Disorder
Psychiatry
Serotonin
Axon Initial Segment
Antibodies

ASJC Scopus subject areas

  • Psychiatry and Mental health

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Serotonin1A Receptors at the Axon Initial Segment of Prefrontal Pyramidal Neurons in Schizophrenia. / Cruz, Dianne A.; Eggan, Stephen M.; Azmitia, Efrain C.; Lewis, David A.

In: American Journal of Psychiatry, Vol. 161, No. 4, 04.2004, p. 739-742.

Research output: Contribution to journalArticle

Cruz, Dianne A. ; Eggan, Stephen M. ; Azmitia, Efrain C. ; Lewis, David A. / Serotonin1A Receptors at the Axon Initial Segment of Prefrontal Pyramidal Neurons in Schizophrenia. In: American Journal of Psychiatry. 2004 ; Vol. 161, No. 4. pp. 739-742.
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