Serotonin neurons, neuroplasticity, and homeostasis of neural tissue

Research output: Contribution to journalArticle

Abstract

Homeostasis is the process by which the internal milieu of the body is able to maintain equilibrium in the face of constant insults from the external world. Endocrine, immune, and vascular systems play pivotal roles in adjusting internal biochemical reactions to counteract assaults from the outside. Despite the vast accumulation of data over the last 50 years, a role for serotonin in brain homeostasis has not been proposed. In this chapter I will review the plasticity and anatomy of serotonergic neurons in integrating external sensory and motor systems as well as internal endocrine, glial and vascular signals with the various cellular elements comprising neural tissue. Steroids and neuropeptides have both been shown to alter the morphology of serotonergic neurons. In turn, alterations in serotonin levels in the adult brain can change the morphology of its target cells. A pivotal role for serotonin in the homeostasis of neural tissue is consistent with the function of serotonin throughout evolution and explains the large number of biological systems, behavioral activities, and clinical diseases associated with serotonergic neurons.

Original languageEnglish (US)
JournalNeuropsychopharmacology
Volume21
Issue number2 SUPPL.
DOIs
StatePublished - Aug 1999

Fingerprint

Neuronal Plasticity
Serotonergic Neurons
Serotonin
Homeostasis
Neurons
Blood Vessels
Brain
Neuropeptides
Neuroglia
Immune System
Anatomy
Steroids

Keywords

  • Co-localization
  • Evolution
  • Neuropeptide
  • Raphe
  • Review
  • Ultrastructure

ASJC Scopus subject areas

  • Pharmacology

Cite this

Serotonin neurons, neuroplasticity, and homeostasis of neural tissue. / Azmitia, Efrain Charles.

In: Neuropsychopharmacology, Vol. 21, No. 2 SUPPL., 08.1999.

Research output: Contribution to journalArticle

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