Serotonergic markers in atopic dermatitis

Aram Rasul, Husameldin El-Nour, Sol Britt Lonne-Rahm, Oscar Fransson, Charlotta Johansson, Björn Johansson, Marwe Zubeidi, Emma Seeberg, Diana Radu Djurfeldt, Efrain Azmitia, Klas Nordlind

Research output: Contribution to journalArticle

Abstract

Stress and anxiety may worsen atopic dermatitis (AD) through the serotonin system. Serotonergic expression was measured in 28 patients with AD in relation to extent of the disease (SCORing of Atopic Dermatitis; SCORAD), pruritus intensity (visual analogue scale; VAS), anxiety traits (Swedish Universities Scales of Personality; SSP) and depression (Montgomery- Åsberg Depression Rating Scale-Self assessment; MADRS-S). Biopsies were taken from lesional and non-lesional AD skin, and investigated for expression of serotonin, its receptors 5-HT1A and 5-HT2AR, and serotonin transporter protein (SERT), using immunohistochemistry. 5-HT1AR-immunoreactivity (ir) was higher in lesional skin in apical epidermis and in mast cell-like cells in dermis, and the 5-HT2AR-ir was higher in apical epidermis and on blood vessels. In contrast, a basement membrane 5-HT2AR-ir signal was higher in non-lesional skin. The distribution of SERT-ir in the basal epidermal layer was higher in lesional skin. Positive and negative correlations were found between serotonergic markers and SCORAD, inflammation, pruritus intensity, anxiety traits, and depression score, indicating that serotonergic mechanisms are involved in AD.

Original languageEnglish (US)
Pages (from-to)732-736
Number of pages5
JournalActa Dermato-Venereologica
Volume96
Issue number6
DOIs
StatePublished - Sep 1 2016

Fingerprint

Atopic Dermatitis
Serotonin Plasma Membrane Transport Proteins
Skin
Anxiety
Pruritus
Depression
Epidermis
Receptor, Serotonin, 5-HT1A
Dermis
Visual Analog Scale
Basement Membrane
Mast Cells
Blood Vessels
Personality
Serotonin
Proteins
Immunohistochemistry
Inflammation
Biopsy

Keywords

  • Atopic dermatitis
  • Inflammation
  • Pruritus
  • Serotonergic system

ASJC Scopus subject areas

  • Dermatology

Cite this

Rasul, A., El-Nour, H., Lonne-Rahm, S. B., Fransson, O., Johansson, C., Johansson, B., ... Nordlind, K. (2016). Serotonergic markers in atopic dermatitis. Acta Dermato-Venereologica, 96(6), 732-736. https://doi.org/10.2340/00015555-2354

Serotonergic markers in atopic dermatitis. / Rasul, Aram; El-Nour, Husameldin; Lonne-Rahm, Sol Britt; Fransson, Oscar; Johansson, Charlotta; Johansson, Björn; Zubeidi, Marwe; Seeberg, Emma; Radu Djurfeldt, Diana; Azmitia, Efrain; Nordlind, Klas.

In: Acta Dermato-Venereologica, Vol. 96, No. 6, 01.09.2016, p. 732-736.

Research output: Contribution to journalArticle

Rasul, A, El-Nour, H, Lonne-Rahm, SB, Fransson, O, Johansson, C, Johansson, B, Zubeidi, M, Seeberg, E, Radu Djurfeldt, D, Azmitia, E & Nordlind, K 2016, 'Serotonergic markers in atopic dermatitis', Acta Dermato-Venereologica, vol. 96, no. 6, pp. 732-736. https://doi.org/10.2340/00015555-2354
Rasul A, El-Nour H, Lonne-Rahm SB, Fransson O, Johansson C, Johansson B et al. Serotonergic markers in atopic dermatitis. Acta Dermato-Venereologica. 2016 Sep 1;96(6):732-736. https://doi.org/10.2340/00015555-2354
Rasul, Aram ; El-Nour, Husameldin ; Lonne-Rahm, Sol Britt ; Fransson, Oscar ; Johansson, Charlotta ; Johansson, Björn ; Zubeidi, Marwe ; Seeberg, Emma ; Radu Djurfeldt, Diana ; Azmitia, Efrain ; Nordlind, Klas. / Serotonergic markers in atopic dermatitis. In: Acta Dermato-Venereologica. 2016 ; Vol. 96, No. 6. pp. 732-736.
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