Septal elicitation of hippocampal theta rhythm after localized de-afferentation of serotoninergic fibers

N. McNaughton, Efrain Azmitia, J. H. Williams, A. Buchan, J. A. Gray

Research output: Contribution to journalArticle

Abstract

Previous experiments using serotonin antagonists and electrolytic raphe lesions suggest that the serotonergic input to the hippocampus inhibits low frequency (<7Hz) theta rhythm in the rat, whereas experiments using raphe stimulation suggest facilitation. The present experiments employed neurotoxic lesions of the serotonergic input to the hippocampus in an attempt to reproduce the effects of systemically administered antagonists. If the septal area is stimulated at frequencies between 6 and 10 Hz in the rat, the threshold current for driving hippocampal theta is minimum at 7.7 Hz. Systemic blockade of serotonergic synapses has been shown to shift this minimum to 6.9 Hz. In the present experiments, neurotoxic lesions were made with injections of 5,7-dihydroxytryptamine into the cingulum bundle, fornix or both. The observed effect depended on the loss of serotonin in the hippocampus, rather than the site of injection, and extensive depletion shifted the minimum to 6.9 Hz. These results indicate that the fornix and cingulum serotonergic inputs to the hippocampus are functionally homogenous, at least with respect to this response; and that the effects of systemic manipulation of serotonin systems on the septal elicitation of hippocampal theta rhythm may be attributed to changes in these two inputs.

Original languageEnglish (US)
Pages (from-to)259-269
Number of pages11
JournalBrain Research
Volume200
Issue number2
DOIs
StatePublished - Nov 3 1980

Fingerprint

Theta Rhythm
Hippocampus
Serotonin
5,7-Dihydroxytryptamine
Septum of Brain
Serotonin Antagonists
Injections
Synapses

Keywords

  • cingulum fornix
  • hippocampal theta rhythm
  • median raphe
  • neurotoxic lesions
  • serotonin

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Septal elicitation of hippocampal theta rhythm after localized de-afferentation of serotoninergic fibers. / McNaughton, N.; Azmitia, Efrain; Williams, J. H.; Buchan, A.; Gray, J. A.

In: Brain Research, Vol. 200, No. 2, 03.11.1980, p. 259-269.

Research output: Contribution to journalArticle

McNaughton, N. ; Azmitia, Efrain ; Williams, J. H. ; Buchan, A. ; Gray, J. A. / Septal elicitation of hippocampal theta rhythm after localized de-afferentation of serotoninergic fibers. In: Brain Research. 1980 ; Vol. 200, No. 2. pp. 259-269.
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