Sensory inputs control the integration of neurogliaform interneurons into cortical circuits

Natalia V. De Marco Garc�a, Rashi Priya, Sebnem N. Tuncdemir, Gordon Fishell, Theofanis Karayannis

Research output: Contribution to journalArticle

Abstract

Neuronal microcircuits in the superficial layers of the mammalian cortex provide the substrate for associative cortical computation. Inhibitory interneurons constitute an essential component of the circuitry and are fundamental to the integration of local and long-range information. Here we report that, during early development, superficially positioned Reelin-expressing neurogliaform interneurons in the mouse somatosensory cortex receive afferent innervation from both cortical and thalamic excitatory sources. Attenuation of ascending sensory, but not intracortical, excitation leads to axo-dendritic morphological defects in these interneurons. Moreover, abrogation of the NMDA receptors through which the thalamic inputs signal results in a similar phenotype, as well as in the selective loss of thalamic and a concomitant increase in intracortical connectivity. These results suggest that thalamic inputs are critical in determining the balance between local and long-range connectivity and are fundamental to the proper integration of Reelin-expressing interneurons into nascent cortical circuits.

Original languageEnglish (US)
Pages (from-to)393-403
Number of pages11
JournalNature Neuroscience
Volume18
Issue number3
DOIs
StatePublished - Mar 27 2015

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Interneurons
Somatosensory Cortex
N-Methyl-D-Aspartate Receptors
Phenotype

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

De Marco Garc�a, N. V., Priya, R., Tuncdemir, S. N., Fishell, G., & Karayannis, T. (2015). Sensory inputs control the integration of neurogliaform interneurons into cortical circuits. Nature Neuroscience, 18(3), 393-403. https://doi.org/10.1038/nn.3946

Sensory inputs control the integration of neurogliaform interneurons into cortical circuits. / De Marco Garc�a, Natalia V.; Priya, Rashi; Tuncdemir, Sebnem N.; Fishell, Gordon; Karayannis, Theofanis.

In: Nature Neuroscience, Vol. 18, No. 3, 27.03.2015, p. 393-403.

Research output: Contribution to journalArticle

De Marco Garc�a, NV, Priya, R, Tuncdemir, SN, Fishell, G & Karayannis, T 2015, 'Sensory inputs control the integration of neurogliaform interneurons into cortical circuits', Nature Neuroscience, vol. 18, no. 3, pp. 393-403. https://doi.org/10.1038/nn.3946
De Marco Garc�a, Natalia V. ; Priya, Rashi ; Tuncdemir, Sebnem N. ; Fishell, Gordon ; Karayannis, Theofanis. / Sensory inputs control the integration of neurogliaform interneurons into cortical circuits. In: Nature Neuroscience. 2015 ; Vol. 18, No. 3. pp. 393-403.
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