Sensorimotor structure of Drosophila larva phototaxis

Elizabeth A. Kane, Marc Gershow, Bruno Afonso, Ivan Larderet, Mason Klein, Ashley R. Carter, Benjamin L. De Bivort, Simon G. Sprecher, Aravinthan D T Samuel

    Research output: Contribution to journalArticle

    Abstract

    The avoidance of light by fly larvae is a classic paradigm for sensorimotor behavior. Here, we use behavioral assays and video microscopy to quantify the sensorimotor structure of phototaxis using the Drosophila larva. Larval locomotion is composed of sequences of runs (periods of forward movement) that are interrupted by abrupt turns, during which the larva pauses and sweeps its head back and forth, probing local light information to determine the direction of the successive run. All phototactic responses are mediated by the same set of sensorimotor transformations that require temporal processing of sensory inputs. Through functional imaging and genetic inactivation of specific neurons downstream of the sensory periphery, we have begun to map these sensorimotor circuits into the larval central brain.We find that specific sensorimotor pathways that govern distinct light-evoked responses begin to segregate at the first relay after the photosensory neurons.

    Original languageEnglish (US)
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume110
    Issue number40
    DOIs
    StatePublished - Oct 1 2013

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    Drosophila
    Larva
    Light
    Video Microscopy
    Sensory Receptor Cells
    Locomotion
    Diptera
    Head
    Neurons
    Brain
    Phototaxis
    Direction compound

    ASJC Scopus subject areas

    • General

    Cite this

    Kane, E. A., Gershow, M., Afonso, B., Larderet, I., Klein, M., Carter, A. R., ... Samuel, A. D. T. (2013). Sensorimotor structure of Drosophila larva phototaxis. Proceedings of the National Academy of Sciences of the United States of America, 110(40). https://doi.org/10.1073/pnas.1215295110

    Sensorimotor structure of Drosophila larva phototaxis. / Kane, Elizabeth A.; Gershow, Marc; Afonso, Bruno; Larderet, Ivan; Klein, Mason; Carter, Ashley R.; De Bivort, Benjamin L.; Sprecher, Simon G.; Samuel, Aravinthan D T.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 40, 01.10.2013.

    Research output: Contribution to journalArticle

    Kane, EA, Gershow, M, Afonso, B, Larderet, I, Klein, M, Carter, AR, De Bivort, BL, Sprecher, SG & Samuel, ADT 2013, 'Sensorimotor structure of Drosophila larva phototaxis', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 40. https://doi.org/10.1073/pnas.1215295110
    Kane, Elizabeth A. ; Gershow, Marc ; Afonso, Bruno ; Larderet, Ivan ; Klein, Mason ; Carter, Ashley R. ; De Bivort, Benjamin L. ; Sprecher, Simon G. ; Samuel, Aravinthan D T. / Sensorimotor structure of Drosophila larva phototaxis. In: Proceedings of the National Academy of Sciences of the United States of America. 2013 ; Vol. 110, No. 40.
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