Sensitization in Aplysia

restoration of transmission in synapses inactivated by long term habituation

Thomas Carew, V. F. Castellucci, E. R. Kandel

Research output: Contribution to journalArticle

Abstract

Long-term habituation of a simple withdrawal reflex in Aplysia leads to an inactivation of synaptic transmission between identified sensory and gill motor neurons that persists for more than 3 weeks. A single sensitizing stimulus rapidly reactivates both the depressed behavioral response and the activated synaptic transmission. Thus sensitization, a simple competitive form of learning, provides a mechanism whereby changing environmental demands can rapidly override the long term memory of habituation.

Original languageEnglish (US)
Pages (from-to)417-419
Number of pages3
JournalScience
Volume205
Issue number4404
StatePublished - 1979

Fingerprint

Aplysia
Synaptic Transmission
Synapses
Long-Term Memory
Motor Neurons
Reflex
Learning

ASJC Scopus subject areas

  • General

Cite this

Sensitization in Aplysia : restoration of transmission in synapses inactivated by long term habituation. / Carew, Thomas; Castellucci, V. F.; Kandel, E. R.

In: Science, Vol. 205, No. 4404, 1979, p. 417-419.

Research output: Contribution to journalArticle

Carew, Thomas ; Castellucci, V. F. ; Kandel, E. R. / Sensitization in Aplysia : restoration of transmission in synapses inactivated by long term habituation. In: Science. 1979 ; Vol. 205, No. 4404. pp. 417-419.
@article{9fefc2ceb680482997981b467e7d1207,
title = "Sensitization in Aplysia: restoration of transmission in synapses inactivated by long term habituation",
abstract = "Long-term habituation of a simple withdrawal reflex in Aplysia leads to an inactivation of synaptic transmission between identified sensory and gill motor neurons that persists for more than 3 weeks. A single sensitizing stimulus rapidly reactivates both the depressed behavioral response and the activated synaptic transmission. Thus sensitization, a simple competitive form of learning, provides a mechanism whereby changing environmental demands can rapidly override the long term memory of habituation.",
author = "Thomas Carew and Castellucci, {V. F.} and Kandel, {E. R.}",
year = "1979",
language = "English (US)",
volume = "205",
pages = "417--419",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4404",

}

TY - JOUR

T1 - Sensitization in Aplysia

T2 - restoration of transmission in synapses inactivated by long term habituation

AU - Carew, Thomas

AU - Castellucci, V. F.

AU - Kandel, E. R.

PY - 1979

Y1 - 1979

N2 - Long-term habituation of a simple withdrawal reflex in Aplysia leads to an inactivation of synaptic transmission between identified sensory and gill motor neurons that persists for more than 3 weeks. A single sensitizing stimulus rapidly reactivates both the depressed behavioral response and the activated synaptic transmission. Thus sensitization, a simple competitive form of learning, provides a mechanism whereby changing environmental demands can rapidly override the long term memory of habituation.

AB - Long-term habituation of a simple withdrawal reflex in Aplysia leads to an inactivation of synaptic transmission between identified sensory and gill motor neurons that persists for more than 3 weeks. A single sensitizing stimulus rapidly reactivates both the depressed behavioral response and the activated synaptic transmission. Thus sensitization, a simple competitive form of learning, provides a mechanism whereby changing environmental demands can rapidly override the long term memory of habituation.

UR - http://www.scopus.com/inward/record.url?scp=0018650103&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018650103&partnerID=8YFLogxK

M3 - Article

VL - 205

SP - 417

EP - 419

JO - Science

JF - Science

SN - 0036-8075

IS - 4404

ER -