Sendai virus infection of mice with protein malnutrition

V. Pena-Cruz, Carol Reiss, K. McIntosh

Research output: Contribution to journalArticle

Abstract

Sendai virus pneumonia was produced in BALB/c mice fed protein-deficient diets in an effort to understand the severity of viral pneumonia in infants in developing countries. Animals on the deficient diet became clinically malnourished, and some aspects of cellular immunity were altered. In protein-deprived animals, the 50% lethal dose of intranasally administered Sendai virus was over 1,000-fold lower, pulmonary virus titers were higher, the infection was prolonged, and lung infection was established at a lower inoculum than in normal animals.

Original languageEnglish (US)
Pages (from-to)3541-3544
Number of pages4
JournalJournal of Virology
Volume63
Issue number8
StatePublished - 1989

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Sendai virus
kwashiorkor
Virus Diseases
Malnutrition
viral pneumonia
lungs
animal proteins
mice
viral load
lethal dose 50
Viral Pneumonia
diet
infection
cell-mediated immunity
pneumonia
Diet
developing countries
Lung
animals
inoculum

ASJC Scopus subject areas

  • Immunology

Cite this

Pena-Cruz, V., Reiss, C., & McIntosh, K. (1989). Sendai virus infection of mice with protein malnutrition. Journal of Virology, 63(8), 3541-3544.

Sendai virus infection of mice with protein malnutrition. / Pena-Cruz, V.; Reiss, Carol; McIntosh, K.

In: Journal of Virology, Vol. 63, No. 8, 1989, p. 3541-3544.

Research output: Contribution to journalArticle

Pena-Cruz, V, Reiss, C & McIntosh, K 1989, 'Sendai virus infection of mice with protein malnutrition', Journal of Virology, vol. 63, no. 8, pp. 3541-3544.
Pena-Cruz, V. ; Reiss, Carol ; McIntosh, K. / Sendai virus infection of mice with protein malnutrition. In: Journal of Virology. 1989 ; Vol. 63, No. 8. pp. 3541-3544.
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