Self-Reported Exposure to ETS (Environmental Tobacco Smoke), Urinary Cotinine, and Oxidative Stress Parameters in Pregnant Women-The Pilot Study

Lubica Argalasova, Ingrid Zitnanova, Diana Vondrova, Monika Dvorakova, Lucia Laubertova, Jana Jurkovicova, Juraj Stofko, Michael Weitzman, Iveta Waczulikova, Martin Simko

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Exposure to ETS (environmental tobacco smoke) is one of the most toxic environmental exposures. OBJECTIVE: To investigate the association of ETS with physiological, biochemical, and psychological indicators, as well as with urine antioxidant capacity (AC) and oxidative damage to lipids in a pilot sample of healthy pregnant women. METHODS: Exposure to ETS was investigated via a validated questionnaire, and urine cotinine and the marker of oxidative damage to lipids via 8-isoprostane concentrations using an ELISA kit. Urine AC was determined by the spectrophotometric Trolox-equivalent antioxidant capacity (TEAC) method. From a sample of pregnant women (n = 319, average age 30.84 ± 5.09 years) in 80, the levels of cotinine and oxidative stress markers were analyzed. RESULTS: Among the 80 pregnant women, 5% (7.4% confirmed by cotinine) reported being current smokers and 25% reported passive smoking in the household (18.8% confirmed by cotinine). The Kappa was 0.78 for smokers and 0.22 for ETS-exposed nonsmokers. Pregnant women in the ETS-exposed group had significantly reduced AC compared to both the nonsmoker (ETS-) and the smoker groups (p < 0.05). Nonsmokers had significantly lower levels of 8-isoprostane than smokers (p < 0.01) and ETS-exposed nonsmokers (p < 0.05). Correlations between urine levels of cotinine and AC were positive in ETS-exposed nonsmokers. CONCLUSION: A harmful association of active and passive smoking and oxidative stress parameters among pregnant women has been indicated.

Original languageEnglish (US)
JournalInternational journal of environmental research and public health
Volume16
Issue number9
DOIs
StatePublished - May 13 2019

Fingerprint

Cotinine
Environmental Exposure
Smoke
Tobacco
Pregnant Women
Oxidative Stress
8-epi-prostaglandin F2alpha
Antioxidants
Urine
Tobacco Smoke Pollution
Lipids
Poisons
Enzyme-Linked Immunosorbent Assay
Psychology

Keywords

  • environmental tobacco smoke (ETS)
  • oxidative stress parameters
  • pregnant women
  • questionnaire
  • urinary cotinine

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Self-Reported Exposure to ETS (Environmental Tobacco Smoke), Urinary Cotinine, and Oxidative Stress Parameters in Pregnant Women-The Pilot Study. / Argalasova, Lubica; Zitnanova, Ingrid; Vondrova, Diana; Dvorakova, Monika; Laubertova, Lucia; Jurkovicova, Jana; Stofko, Juraj; Weitzman, Michael; Waczulikova, Iveta; Simko, Martin.

In: International journal of environmental research and public health, Vol. 16, No. 9, 13.05.2019.

Research output: Contribution to journalArticle

Argalasova, Lubica ; Zitnanova, Ingrid ; Vondrova, Diana ; Dvorakova, Monika ; Laubertova, Lucia ; Jurkovicova, Jana ; Stofko, Juraj ; Weitzman, Michael ; Waczulikova, Iveta ; Simko, Martin. / Self-Reported Exposure to ETS (Environmental Tobacco Smoke), Urinary Cotinine, and Oxidative Stress Parameters in Pregnant Women-The Pilot Study. In: International journal of environmental research and public health. 2019 ; Vol. 16, No. 9.
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T1 - Self-Reported Exposure to ETS (Environmental Tobacco Smoke), Urinary Cotinine, and Oxidative Stress Parameters in Pregnant Women-The Pilot Study

AU - Argalasova, Lubica

AU - Zitnanova, Ingrid

AU - Vondrova, Diana

AU - Dvorakova, Monika

AU - Laubertova, Lucia

AU - Jurkovicova, Jana

AU - Stofko, Juraj

AU - Weitzman, Michael

AU - Waczulikova, Iveta

AU - Simko, Martin

PY - 2019/5/13

Y1 - 2019/5/13

N2 - BACKGROUND: Exposure to ETS (environmental tobacco smoke) is one of the most toxic environmental exposures. OBJECTIVE: To investigate the association of ETS with physiological, biochemical, and psychological indicators, as well as with urine antioxidant capacity (AC) and oxidative damage to lipids in a pilot sample of healthy pregnant women. METHODS: Exposure to ETS was investigated via a validated questionnaire, and urine cotinine and the marker of oxidative damage to lipids via 8-isoprostane concentrations using an ELISA kit. Urine AC was determined by the spectrophotometric Trolox-equivalent antioxidant capacity (TEAC) method. From a sample of pregnant women (n = 319, average age 30.84 ± 5.09 years) in 80, the levels of cotinine and oxidative stress markers were analyzed. RESULTS: Among the 80 pregnant women, 5% (7.4% confirmed by cotinine) reported being current smokers and 25% reported passive smoking in the household (18.8% confirmed by cotinine). The Kappa was 0.78 for smokers and 0.22 for ETS-exposed nonsmokers. Pregnant women in the ETS-exposed group had significantly reduced AC compared to both the nonsmoker (ETS-) and the smoker groups (p < 0.05). Nonsmokers had significantly lower levels of 8-isoprostane than smokers (p < 0.01) and ETS-exposed nonsmokers (p < 0.05). Correlations between urine levels of cotinine and AC were positive in ETS-exposed nonsmokers. CONCLUSION: A harmful association of active and passive smoking and oxidative stress parameters among pregnant women has been indicated.

AB - BACKGROUND: Exposure to ETS (environmental tobacco smoke) is one of the most toxic environmental exposures. OBJECTIVE: To investigate the association of ETS with physiological, biochemical, and psychological indicators, as well as with urine antioxidant capacity (AC) and oxidative damage to lipids in a pilot sample of healthy pregnant women. METHODS: Exposure to ETS was investigated via a validated questionnaire, and urine cotinine and the marker of oxidative damage to lipids via 8-isoprostane concentrations using an ELISA kit. Urine AC was determined by the spectrophotometric Trolox-equivalent antioxidant capacity (TEAC) method. From a sample of pregnant women (n = 319, average age 30.84 ± 5.09 years) in 80, the levels of cotinine and oxidative stress markers were analyzed. RESULTS: Among the 80 pregnant women, 5% (7.4% confirmed by cotinine) reported being current smokers and 25% reported passive smoking in the household (18.8% confirmed by cotinine). The Kappa was 0.78 for smokers and 0.22 for ETS-exposed nonsmokers. Pregnant women in the ETS-exposed group had significantly reduced AC compared to both the nonsmoker (ETS-) and the smoker groups (p < 0.05). Nonsmokers had significantly lower levels of 8-isoprostane than smokers (p < 0.01) and ETS-exposed nonsmokers (p < 0.05). Correlations between urine levels of cotinine and AC were positive in ETS-exposed nonsmokers. CONCLUSION: A harmful association of active and passive smoking and oxidative stress parameters among pregnant women has been indicated.

KW - environmental tobacco smoke (ETS)

KW - oxidative stress parameters

KW - pregnant women

KW - questionnaire

KW - urinary cotinine

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U2 - 10.3390/ijerph16091656

DO - 10.3390/ijerph16091656

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JO - International Journal of Environmental Research and Public Health

JF - International Journal of Environmental Research and Public Health

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