Self-report measures of antiretroviral therapy adherence: A review with recommendations for HIV research and clinical management

Jane M. Simoni, Ann E. Kurth, Cynthia R. Pearson, David W. Pantalone, Joseph O. Merrill, Pamela A. Frick

Research output: Contribution to journalReview article

Abstract

A review of 77 studies employing self-report measures of antiretroviral adherence published 1/1996 through 8/2004 revealed great variety in adherence assessment item content, format, and response options. Recall periods ranged from 2 to 365 days (mode=7 days). The most common cutoff for optimal adherence was 100% (21/48 studies, or 44%). In 27 of 34 recall periods (79%), self-reported adherence was associated with adherence as assessed with other indirect measures. Data from 57 of 67 recall periods (84%) indicated self-reported adherence was significantly associated with HIV-1 RNA viral load; in 16 of 26 (62%), it was associated with CD4 count. Clearly, the field would benefit from item standardization and a priori definitions and operationalizations of adherence. We conclude that even brief self-report measures of antiretroviral adherence can be robust, and recommend items and strategies for HIV research and clinical management.

Original languageEnglish (US)
Pages (from-to)227-245
Number of pages19
JournalAIDS and Behavior
Volume10
Issue number3
DOIs
StatePublished - May 1 2006

Keywords

  • Antiretroviral
  • HIV/AIDS
  • Medication adherence
  • Self-report
  • Viral load

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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