Self-replication of information-bearing nanoscale patterns

Tong Wang, Ruojie Sha, Rémi Dreyfus, Mirjam E. Leunissen, Corinna Maass, David J. Pine, Paul M. Chaikin, Nadrian C. Seeman

Research output: Contribution to journalArticle

Abstract

DNA molecules provide what is probably the most iconic example of self-replication-the ability of a system to replicate, or make copies of, itself. In living cells the process is mediated by enzymes and occurs autonomously, with the number of replicas increasing exponentially over time without the need for external manipulation. Self-replication has also been implemented with synthetic systems, including RNA enzymes designed to undergo self-sustained exponential amplification. An exciting next step would be to use self-replication in materials fabrication, which requires robust and general systems capable of copying and amplifying functional materials or structures. Here we report a first development in this direction, using DNA tile motifs that can recognize and bind complementary tiles in a pre-programmed fashion. We first design tile motifs so they form a seven-tile seed sequence; then use the seeds to instruct the formation of a first generation of complementary seven-tile daughter sequences; and finally use the daughters to instruct the formation of seven-tile granddaughter sequences that are identical to the initial seed sequences. Considering that DNA is a functional material that can organize itself and other molecules into useful structures, our findings raise the tantalizing prospect that we may one day be able to realize self-replicating materials with various patterns or useful functions.

Original languageEnglish (US)
Pages (from-to)225-228
Number of pages4
JournalNature
Volume478
Issue number7368
DOIs
StatePublished - Oct 13 2011

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Seeds
Nucleotide Motifs
DNA
Enzymes
RNA
Direction compound

ASJC Scopus subject areas

  • General

Cite this

Wang, T., Sha, R., Dreyfus, R., Leunissen, M. E., Maass, C., Pine, D. J., ... Seeman, N. C. (2011). Self-replication of information-bearing nanoscale patterns. Nature, 478(7368), 225-228. https://doi.org/10.1038/nature10500

Self-replication of information-bearing nanoscale patterns. / Wang, Tong; Sha, Ruojie; Dreyfus, Rémi; Leunissen, Mirjam E.; Maass, Corinna; Pine, David J.; Chaikin, Paul M.; Seeman, Nadrian C.

In: Nature, Vol. 478, No. 7368, 13.10.2011, p. 225-228.

Research output: Contribution to journalArticle

Wang, T, Sha, R, Dreyfus, R, Leunissen, ME, Maass, C, Pine, DJ, Chaikin, PM & Seeman, NC 2011, 'Self-replication of information-bearing nanoscale patterns', Nature, vol. 478, no. 7368, pp. 225-228. https://doi.org/10.1038/nature10500
Wang T, Sha R, Dreyfus R, Leunissen ME, Maass C, Pine DJ et al. Self-replication of information-bearing nanoscale patterns. Nature. 2011 Oct 13;478(7368):225-228. https://doi.org/10.1038/nature10500
Wang, Tong ; Sha, Ruojie ; Dreyfus, Rémi ; Leunissen, Mirjam E. ; Maass, Corinna ; Pine, David J. ; Chaikin, Paul M. ; Seeman, Nadrian C. / Self-replication of information-bearing nanoscale patterns. In: Nature. 2011 ; Vol. 478, No. 7368. pp. 225-228.
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