Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery

Dinesh Shetty, Tina Skorjanc, Mark Anthony Olson, Ali Trabolsi

    Research output: Contribution to journalArticle

    Abstract

    Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.

    Original languageEnglish (US)
    Pages (from-to)8876-8879
    Number of pages4
    JournalChemical Communications
    Volume55
    Issue number60
    DOIs
    StatePublished - Jan 1 2019

    Fingerprint

    Nanocapsules
    Camptothecin
    Imines
    Self assembly
    Cells
    Cytotoxicity
    Pharmaceutical Preparations
    Tumors
    calix(4)arene

    ASJC Scopus subject areas

    • Catalysis
    • Electronic, Optical and Magnetic Materials
    • Ceramics and Composites
    • Chemistry(all)
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Materials Chemistry

    Cite this

    Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery. / Shetty, Dinesh; Skorjanc, Tina; Olson, Mark Anthony; Trabolsi, Ali.

    In: Chemical Communications, Vol. 55, No. 60, 01.01.2019, p. 8876-8879.

    Research output: Contribution to journalArticle

    Shetty, Dinesh ; Skorjanc, Tina ; Olson, Mark Anthony ; Trabolsi, Ali. / Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery. In: Chemical Communications. 2019 ; Vol. 55, No. 60. pp. 8876-8879.
    @article{eb0285c6bc964d37ae9388eb849bb8f6,
    title = "Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery",
    abstract = "Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.",
    author = "Dinesh Shetty and Tina Skorjanc and Olson, {Mark Anthony} and Ali Trabolsi",
    year = "2019",
    month = "1",
    day = "1",
    doi = "10.1039/c9cc02214g",
    language = "English (US)",
    volume = "55",
    pages = "8876--8879",
    journal = "Chemical Communications",
    issn = "1359-7345",
    publisher = "Royal Society of Chemistry",
    number = "60",

    }

    TY - JOUR

    T1 - Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery

    AU - Shetty, Dinesh

    AU - Skorjanc, Tina

    AU - Olson, Mark Anthony

    AU - Trabolsi, Ali

    PY - 2019/1/1

    Y1 - 2019/1/1

    N2 - Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.

    AB - Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.

    UR - http://www.scopus.com/inward/record.url?scp=85069771942&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=85069771942&partnerID=8YFLogxK

    U2 - 10.1039/c9cc02214g

    DO - 10.1039/c9cc02214g

    M3 - Article

    VL - 55

    SP - 8876

    EP - 8879

    JO - Chemical Communications

    JF - Chemical Communications

    SN - 1359-7345

    IS - 60

    ER -