Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery

Dinesh Shetty, Tina Skorjanc, Mark Anthony Olson, Ali Trabolsi

Research output: Contribution to journalArticle

Abstract

Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.

Original languageEnglish (US)
Pages (from-to)8876-8879
Number of pages4
JournalChemical Communications
Volume55
Issue number60
DOIs
StatePublished - Jan 1 2019

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Nanocapsules
Camptothecin
Imines
Self assembly
Cells
Cytotoxicity
Pharmaceutical Preparations
Tumors
calix(4)arene

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery. / Shetty, Dinesh; Skorjanc, Tina; Olson, Mark Anthony; Trabolsi, Ali.

In: Chemical Communications, Vol. 55, No. 60, 01.01.2019, p. 8876-8879.

Research output: Contribution to journalArticle

Shetty, Dinesh ; Skorjanc, Tina ; Olson, Mark Anthony ; Trabolsi, Ali. / Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery. In: Chemical Communications. 2019 ; Vol. 55, No. 60. pp. 8876-8879.
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