Self-assembly of a four-helix bundle on a DNA quadruplex

Brooke A. Rosenzweig, Andrew Hamilton

Research output: Contribution to journalArticle

Abstract

Come together: A novel method for assembling monomers and controlling structure of a de novo helix bundle protein is described. A guanine (G)-rich oligodeoxynucleotide scaffold forms a hydrogen-bonded DNA quadruplex in the presence of potassium counterions, thereby inducing a helical structure and fourfold stoichiometry in conjugated, amphiphilic peptide sequences. The DNA scaffold shows potential for rapidly assembling designed proteins.

Original languageEnglish (US)
Pages (from-to)2749-2751
Number of pages3
JournalAngewandte Chemie - International Edition
Volume48
Issue number15
DOIs
StatePublished - Mar 30 2009

Fingerprint

G-Quadruplexes
Scaffolds
Self assembly
DNA
Proteins
Forms (concrete)
Oligodeoxyribonucleotides
Guanine
Scaffolds (biology)
Stoichiometry
Peptides
Potassium
Hydrogen
Monomers

Keywords

  • DNA structures
  • G-quadruplexes
  • Helical structures
  • Protein design
  • Self-assembly

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Medicine(all)

Cite this

Self-assembly of a four-helix bundle on a DNA quadruplex. / Rosenzweig, Brooke A.; Hamilton, Andrew.

In: Angewandte Chemie - International Edition, Vol. 48, No. 15, 30.03.2009, p. 2749-2751.

Research output: Contribution to journalArticle

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