Selectivity in postencoding connectivity with high-level visual cortex is associated with reward-motivated memory

Vishnu P. Murty, Alexa Tompary, R. Alison Adcock, Lila Davachi

Research output: Contribution to journalArticle

Abstract

Reward motivation has been demonstrated to enhance declarative memory by facilitating systems-level consolidation. Although highreward information is often intermixed with lower reward information during an experience, memory for high value information is prioritized. How is this selectivity achieved? One possibility is that postencoding consolidation processes bias memory strengthening to those representations associated with higher reward. To test this hypothesis, we investigated the influence of differential reward motivation on the selectivity of postencoding markers of systems-level memory consolidation. Human participants encoded intermixed, trial-unique memoranda that were associated with either high or low-value during fMRI acquisition. Encoding was interleaved with periods of rest, allowing us to investigate experience-dependent changes in connectivity as they related to later memory. Behaviorally, we found that reward motivation enhanced 24 h associative memory. Analysis of patterns of postencoding connectivity showed that, even though learning trials were intermixed, there was significantly greater connectivity with regions of high-level, category-selective visual cortex associated with high-reward trials. Specifically, increased connectivity of category-selective visual cortex with both the VTA and the anterior hippocampus predicted associative memory for high- but not low-reward memories. Critically, these results were independent of encoding-related connectivity and univariate activity measures. Thus, these findings support a model by which the selective stabilization of memories for salient events is supported by postencoding interactions with sensory cortex associated with reward.

Original languageEnglish (US)
Pages (from-to)537-545
Number of pages9
JournalJournal of Neuroscience
Volume37
Issue number3
DOIs
StatePublished - Jan 18 2017

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Visual Cortex
Reward
Motivation
Hippocampus
Magnetic Resonance Imaging
Learning

Keywords

  • Category-selective visual cortex
  • Consolidation
  • Hippocampus
  • Rest
  • Reward
  • VTA

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Selectivity in postencoding connectivity with high-level visual cortex is associated with reward-motivated memory. / Murty, Vishnu P.; Tompary, Alexa; Adcock, R. Alison; Davachi, Lila.

In: Journal of Neuroscience, Vol. 37, No. 3, 18.01.2017, p. 537-545.

Research output: Contribution to journalArticle

Murty, Vishnu P. ; Tompary, Alexa ; Adcock, R. Alison ; Davachi, Lila. / Selectivity in postencoding connectivity with high-level visual cortex is associated with reward-motivated memory. In: Journal of Neuroscience. 2017 ; Vol. 37, No. 3. pp. 537-545.
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