Selective effect of inhibitors on inner mitochondrial membrane channels

Yuri N. Antonenko, Kathleen W. Kinnally, Sean Perini, Henry Tedeschi

Research output: Contribution to journal › Article

Abstract

The effect of amphiphilic cationic drugs on the channel activity of the mitochondrial inner membrane was examined with patch-clamp techniques. The therapeutic drugs amiodarone, propranolol and quinine reduced the probability of being open for the multiconductance channel (MCC) activity (levels from 30 pS to over I nS). While amiodarone decreased the probability of being open for the voltage dependent ∼ 100 pS channel, it increased the conductance 42 ± 20% (mean ± SD, n = 6) with no significant change in mean open time. Similar results were obtained with propranolol. These data indicate that the ∼ 100 pS channel is distinct from MCC activity.

Original languageEnglish (US)
Pages (from-to)89-93
Number of pages5
JournalFEBS Letters
Volume285
Issue number1
DOIs
StatePublished - Jul 8 1991

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Amiodarone
Mitochondrial Membranes
Ion Channels
Propranolol
Quinine
Clamping devices
Patch-Clamp Techniques
Pharmaceutical Preparations
Membranes
Electric potential
Therapeutics

Keywords

  • Inner mitochondrial membrane
  • Mitochondrial channel
  • Patch-clamp
  • Pharmacology

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Antonenko, Y. N., Kinnally, K. W., Perini, S., & Tedeschi, H. (1991). Selective effect of inhibitors on inner mitochondrial membrane channels. FEBS Letters, 285(1), 89-93. https://doi.org/10.1016/0014-5793(91)80731-H

Selective effect of inhibitors on inner mitochondrial membrane channels. / Antonenko, Yuri N.; Kinnally, Kathleen W.; Perini, Sean; Tedeschi, Henry.

In: FEBS Letters, Vol. 285, No. 1, 08.07.1991, p. 89-93.

Research output: Contribution to journal › Article

Antonenko, YN, Kinnally, KW, Perini, S & Tedeschi, H 1991, 'Selective effect of inhibitors on inner mitochondrial membrane channels', FEBS Letters, vol. 285, no. 1, pp. 89-93. https://doi.org/10.1016/0014-5793(91)80731-H
Antonenko YN, Kinnally KW, Perini S, Tedeschi H. Selective effect of inhibitors on inner mitochondrial membrane channels. FEBS Letters. 1991 Jul 8;285(1):89-93. https://doi.org/10.1016/0014-5793(91)80731-H
Antonenko, Yuri N. ; Kinnally, Kathleen W. ; Perini, Sean ; Tedeschi, Henry. / Selective effect of inhibitors on inner mitochondrial membrane channels. In: FEBS Letters. 1991 ; Vol. 285, No. 1. pp. 89-93.
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