Abstract
The effect of amphiphilic cationic drugs on the channel activity of the mitochondrial inner membrane was examined with patch-clamp techniques. The therapeutic drugs amiodarone, propranolol and quinine reduced the probability of being open for the multiconductance channel (MCC) activity (levels from 30 pS to over I nS). While amiodarone decreased the probability of being open for the voltage dependent ∼ 100 pS channel, it increased the conductance 42 ± 20% (mean ± SD, n = 6) with no significant change in mean open time. Similar results were obtained with propranolol. These data indicate that the ∼ 100 pS channel is distinct from MCC activity.
Original language | English (US) |
---|---|
Pages (from-to) | 89-93 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 285 |
Issue number | 1 |
DOIs | |
State | Published - Jul 8 1991 |
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Keywords
- Inner mitochondrial membrane
- Mitochondrial channel
- Patch-clamp
- Pharmacology
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Selective effect of inhibitors on inner mitochondrial membrane channels. / Antonenko, Yuri N.; Kinnally, Kathleen W.; Perini, Sean; Tedeschi, Henry.
In: FEBS Letters, Vol. 285, No. 1, 08.07.1991, p. 89-93.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Selective effect of inhibitors on inner mitochondrial membrane channels
AU - Antonenko, Yuri N.
AU - Kinnally, Kathleen W.
AU - Perini, Sean
AU - Tedeschi, Henry
PY - 1991/7/8
Y1 - 1991/7/8
N2 - The effect of amphiphilic cationic drugs on the channel activity of the mitochondrial inner membrane was examined with patch-clamp techniques. The therapeutic drugs amiodarone, propranolol and quinine reduced the probability of being open for the multiconductance channel (MCC) activity (levels from 30 pS to over I nS). While amiodarone decreased the probability of being open for the voltage dependent ∼ 100 pS channel, it increased the conductance 42 ± 20% (mean ± SD, n = 6) with no significant change in mean open time. Similar results were obtained with propranolol. These data indicate that the ∼ 100 pS channel is distinct from MCC activity.
AB - The effect of amphiphilic cationic drugs on the channel activity of the mitochondrial inner membrane was examined with patch-clamp techniques. The therapeutic drugs amiodarone, propranolol and quinine reduced the probability of being open for the multiconductance channel (MCC) activity (levels from 30 pS to over I nS). While amiodarone decreased the probability of being open for the voltage dependent ∼ 100 pS channel, it increased the conductance 42 ± 20% (mean ± SD, n = 6) with no significant change in mean open time. Similar results were obtained with propranolol. These data indicate that the ∼ 100 pS channel is distinct from MCC activity.
KW - Inner mitochondrial membrane
KW - Mitochondrial channel
KW - Patch-clamp
KW - Pharmacology
UR - http://www.scopus.com/inward/record.url?scp=0025856182&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025856182&partnerID=8YFLogxK
U2 - 10.1016/0014-5793(91)80731-H
DO - 10.1016/0014-5793(91)80731-H
M3 - Article
C2 - 1712321
AN - SCOPUS:0025856182
VL - 285
SP - 89
EP - 93
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 1
ER -