Selection at linked sites shapes heritable phenotypic variation in C. elegans

Matthew V. Rockman, Sonja S. Skrovanek, Leonid Kruglyak

Research output: Contribution to journalArticle

Abstract

Mutation generates the heritable variation that genetic drift and natural selection shape. In classical quantitative genetic models, drift is a function of the effective population size and acts uniformly across traits, whereas mutation and selection act trait-specifically. We identified thousands of quantitative trait loci (QTLs) influencing transcript abundance traits in a cross of two Caenorhabditis elegans strains; although trait-specific mutation and selection explained some of the observed pattern of QTL distribution, the pattern was better explained by trait-independent variation in the intensity of selection on linked sites. Our results suggest that traits in C. elegans exhibit different levels of variation less because of their own attributes than because of differences in the effective population sizes of the genomic regions harboring their underlying loci.

Original languageEnglish (US)
Pages (from-to)372-376
Number of pages5
JournalScience
Volume330
Issue number6002
DOIs
StatePublished - Oct 15 2010

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Genetic Drift
Quantitative Trait Loci
Caenorhabditis elegans
Population Density
Mutation
Metagenomics
Genetic Selection
Genetic Models

ASJC Scopus subject areas

  • General
  • Medicine(all)

Cite this

Selection at linked sites shapes heritable phenotypic variation in C. elegans. / Rockman, Matthew V.; Skrovanek, Sonja S.; Kruglyak, Leonid.

In: Science, Vol. 330, No. 6002, 15.10.2010, p. 372-376.

Research output: Contribution to journalArticle

Rockman, Matthew V. ; Skrovanek, Sonja S. ; Kruglyak, Leonid. / Selection at linked sites shapes heritable phenotypic variation in C. elegans. In: Science. 2010 ; Vol. 330, No. 6002. pp. 372-376.
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