Segmentation of serial MRI of TBI patients using personalized atlas construction and topological change estimation

Bo Wang, Marcel Prastawa, Suyash P. Awate, Andrei Irimia, Micah C. Chambers, Paul M. Vespa, John D. Van Horn, Guido Gerig

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Traumatic brain injury (TBI) due to falls, car accidents, and warfare affects millions of people annually. Determining personalized therapy and assessment of treatment efficacy can substantially benefit from longitudinal (4D) magnetic resonance imaging (MRI). In this paper, we propose a method for segmenting longitudinal brain MR images with TBI using personalized atlas construction. Longitudinal images with TBI typically present topological changes over time due to the effect of the impact force on tissue, skull, and blood vessels and the recovery process. We address this issue by defining a novel atlas construction scheme that explicitly models the effect of topological changes. Our method automatically estimates the probability of topological changes jointly with the personalized atlas. We demonstrate the effectiveness of this approach on MR images with TBI that also have been segmented by human raters, where our method that integrates 4D information yields improved validation measures compared to temporally independent segmentations.

    Original languageEnglish (US)
    Title of host publication2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Proceedings
    Pages1152-1155
    Number of pages4
    DOIs
    StatePublished - 2012
    Event2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Barcelona, Spain
    Duration: May 2 2012May 5 2012

    Other

    Other2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012
    CountrySpain
    CityBarcelona
    Period5/2/125/5/12

    Fingerprint

    Atlases
    Magnetic resonance
    Brain
    Magnetic Resonance Imaging
    Imaging techniques
    Skull
    Military operations
    Accidents
    Blood Vessels
    Blood vessels
    Railroad cars
    Traumatic Brain Injury
    Tissue
    Recovery
    Therapeutics

    Keywords

    • 4D pathology segmentation
    • atlas construction
    • longitudinal MRI
    • topological change estimation

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Radiology Nuclear Medicine and imaging

    Cite this

    Wang, B., Prastawa, M., Awate, S. P., Irimia, A., Chambers, M. C., Vespa, P. M., ... Gerig, G. (2012). Segmentation of serial MRI of TBI patients using personalized atlas construction and topological change estimation. In 2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Proceedings (pp. 1152-1155). [6235764] https://doi.org/10.1109/ISBI.2012.6235764

    Segmentation of serial MRI of TBI patients using personalized atlas construction and topological change estimation. / Wang, Bo; Prastawa, Marcel; Awate, Suyash P.; Irimia, Andrei; Chambers, Micah C.; Vespa, Paul M.; Van Horn, John D.; Gerig, Guido.

    2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Proceedings. 2012. p. 1152-1155 6235764.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Wang, B, Prastawa, M, Awate, SP, Irimia, A, Chambers, MC, Vespa, PM, Van Horn, JD & Gerig, G 2012, Segmentation of serial MRI of TBI patients using personalized atlas construction and topological change estimation. in 2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Proceedings., 6235764, pp. 1152-1155, 2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012, Barcelona, Spain, 5/2/12. https://doi.org/10.1109/ISBI.2012.6235764
    Wang B, Prastawa M, Awate SP, Irimia A, Chambers MC, Vespa PM et al. Segmentation of serial MRI of TBI patients using personalized atlas construction and topological change estimation. In 2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Proceedings. 2012. p. 1152-1155. 6235764 https://doi.org/10.1109/ISBI.2012.6235764
    Wang, Bo ; Prastawa, Marcel ; Awate, Suyash P. ; Irimia, Andrei ; Chambers, Micah C. ; Vespa, Paul M. ; Van Horn, John D. ; Gerig, Guido. / Segmentation of serial MRI of TBI patients using personalized atlas construction and topological change estimation. 2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Proceedings. 2012. pp. 1152-1155
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