Security implications of cyberphysical digital microfluidic biochips

Sk Subidh Ali, Mohamed Ibrahim, Ozgur Sinanoglu, Krishnendu Chakrabarty, Ramesh Karri

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A digital microfluidic biochip (DMFB) is an emerging technology that enables miniaturized analysis systems for point-of-care clinical diagnostics, DNA sequencing, and environmental monitoring. A DMFB reduces the rate of sample and reagent consumption, and automates the analysis of assays. In this paper, we highlight the security vulnerabilities of DMFBs by identifying two potential attacks on a DMFB that performs enzymatic glucose assay on serum. In the first attack, the attacker adjusts the concentration of the glucose sample and thereby modifies the final result. In the second attack, the calibration curve of the assay operation is maliciously modified in order to make it deviate from the nominal/golden calibration curve. We demonstrate these attacks using a digital microluidics synthesis simulator. The results show that the attacks are stealthy as they do not result in any noticeable change in the DMFB synthesis.

Original languageEnglish (US)
Title of host publicationProceedings of the 33rd IEEE International Conference on Computer Design, ICCD 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages483-486
Number of pages4
ISBN (Print)9781467371650
DOIs
StatePublished - Dec 14 2015
Event33rd IEEE International Conference on Computer Design, ICCD 2015 - New York City, United States
Duration: Oct 18 2015Oct 21 2015

Other

Other33rd IEEE International Conference on Computer Design, ICCD 2015
CountryUnited States
CityNew York City
Period10/18/1510/21/15

Fingerprint

Digital microfluidics
Biochips
Assays
Glucose
Calibration
DNA
Simulators
Monitoring

ASJC Scopus subject areas

  • Computer Graphics and Computer-Aided Design
  • Computer Science Applications

Cite this

Ali, S. S., Ibrahim, M., Sinanoglu, O., Chakrabarty, K., & Karri, R. (2015). Security implications of cyberphysical digital microfluidic biochips. In Proceedings of the 33rd IEEE International Conference on Computer Design, ICCD 2015 (pp. 483-486). [7357154] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICCD.2015.7357154

Security implications of cyberphysical digital microfluidic biochips. / Ali, Sk Subidh; Ibrahim, Mohamed; Sinanoglu, Ozgur; Chakrabarty, Krishnendu; Karri, Ramesh.

Proceedings of the 33rd IEEE International Conference on Computer Design, ICCD 2015. Institute of Electrical and Electronics Engineers Inc., 2015. p. 483-486 7357154.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ali, SS, Ibrahim, M, Sinanoglu, O, Chakrabarty, K & Karri, R 2015, Security implications of cyberphysical digital microfluidic biochips. in Proceedings of the 33rd IEEE International Conference on Computer Design, ICCD 2015., 7357154, Institute of Electrical and Electronics Engineers Inc., pp. 483-486, 33rd IEEE International Conference on Computer Design, ICCD 2015, New York City, United States, 10/18/15. https://doi.org/10.1109/ICCD.2015.7357154
Ali SS, Ibrahim M, Sinanoglu O, Chakrabarty K, Karri R. Security implications of cyberphysical digital microfluidic biochips. In Proceedings of the 33rd IEEE International Conference on Computer Design, ICCD 2015. Institute of Electrical and Electronics Engineers Inc. 2015. p. 483-486. 7357154 https://doi.org/10.1109/ICCD.2015.7357154
Ali, Sk Subidh ; Ibrahim, Mohamed ; Sinanoglu, Ozgur ; Chakrabarty, Krishnendu ; Karri, Ramesh. / Security implications of cyberphysical digital microfluidic biochips. Proceedings of the 33rd IEEE International Conference on Computer Design, ICCD 2015. Institute of Electrical and Electronics Engineers Inc., 2015. pp. 483-486
@inproceedings{a5901d0782d5455bb5353951e005017e,
title = "Security implications of cyberphysical digital microfluidic biochips",
abstract = "A digital microfluidic biochip (DMFB) is an emerging technology that enables miniaturized analysis systems for point-of-care clinical diagnostics, DNA sequencing, and environmental monitoring. A DMFB reduces the rate of sample and reagent consumption, and automates the analysis of assays. In this paper, we highlight the security vulnerabilities of DMFBs by identifying two potential attacks on a DMFB that performs enzymatic glucose assay on serum. In the first attack, the attacker adjusts the concentration of the glucose sample and thereby modifies the final result. In the second attack, the calibration curve of the assay operation is maliciously modified in order to make it deviate from the nominal/golden calibration curve. We demonstrate these attacks using a digital microluidics synthesis simulator. The results show that the attacks are stealthy as they do not result in any noticeable change in the DMFB synthesis.",
author = "Ali, {Sk Subidh} and Mohamed Ibrahim and Ozgur Sinanoglu and Krishnendu Chakrabarty and Ramesh Karri",
year = "2015",
month = "12",
day = "14",
doi = "10.1109/ICCD.2015.7357154",
language = "English (US)",
isbn = "9781467371650",
pages = "483--486",
booktitle = "Proceedings of the 33rd IEEE International Conference on Computer Design, ICCD 2015",
publisher = "Institute of Electrical and Electronics Engineers Inc.",

}

TY - GEN

T1 - Security implications of cyberphysical digital microfluidic biochips

AU - Ali, Sk Subidh

AU - Ibrahim, Mohamed

AU - Sinanoglu, Ozgur

AU - Chakrabarty, Krishnendu

AU - Karri, Ramesh

PY - 2015/12/14

Y1 - 2015/12/14

N2 - A digital microfluidic biochip (DMFB) is an emerging technology that enables miniaturized analysis systems for point-of-care clinical diagnostics, DNA sequencing, and environmental monitoring. A DMFB reduces the rate of sample and reagent consumption, and automates the analysis of assays. In this paper, we highlight the security vulnerabilities of DMFBs by identifying two potential attacks on a DMFB that performs enzymatic glucose assay on serum. In the first attack, the attacker adjusts the concentration of the glucose sample and thereby modifies the final result. In the second attack, the calibration curve of the assay operation is maliciously modified in order to make it deviate from the nominal/golden calibration curve. We demonstrate these attacks using a digital microluidics synthesis simulator. The results show that the attacks are stealthy as they do not result in any noticeable change in the DMFB synthesis.

AB - A digital microfluidic biochip (DMFB) is an emerging technology that enables miniaturized analysis systems for point-of-care clinical diagnostics, DNA sequencing, and environmental monitoring. A DMFB reduces the rate of sample and reagent consumption, and automates the analysis of assays. In this paper, we highlight the security vulnerabilities of DMFBs by identifying two potential attacks on a DMFB that performs enzymatic glucose assay on serum. In the first attack, the attacker adjusts the concentration of the glucose sample and thereby modifies the final result. In the second attack, the calibration curve of the assay operation is maliciously modified in order to make it deviate from the nominal/golden calibration curve. We demonstrate these attacks using a digital microluidics synthesis simulator. The results show that the attacks are stealthy as they do not result in any noticeable change in the DMFB synthesis.

UR - http://www.scopus.com/inward/record.url?scp=84962367669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962367669&partnerID=8YFLogxK

U2 - 10.1109/ICCD.2015.7357154

DO - 10.1109/ICCD.2015.7357154

M3 - Conference contribution

AN - SCOPUS:84962367669

SN - 9781467371650

SP - 483

EP - 486

BT - Proceedings of the 33rd IEEE International Conference on Computer Design, ICCD 2015

PB - Institute of Electrical and Electronics Engineers Inc.

ER -