Salivary levels of N-nitrosamines and some metabolites after IP injection of N-nitrosamines in rats

J. H. Fliessbach, Joseph Guttenplan

Research output: Contribution to journalArticle

Abstract

The carcinogens N-nitrosomethylamine (DMN) and N-nitrosodiethylamine (DEN) were detected in rat saliva by gas liquid chromatography or HPLC after their ip injections. Salivary levels were equal to or greater than blood levels. A fairly linear dose response in salivary levels was observed in the range of 1-50 mg/kg. Salivary levels of DMN and DEN decreased between 0.5 and 1.0 hr after administration with the decrease becoming more prominent at lower doses. Formaldehyde and bicarbonate, metabolites of DMN, were also detected in rat saliva.

Original languageEnglish (US)
Pages (from-to)283-291
Number of pages9
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume33
Issue number2
StatePublished - 1981

Fingerprint

Nitrosamines
Metabolites
Saliva
Rats
Diethylnitrosamine
Injections
Liquid chromatography
Bicarbonates
Gas chromatography
Gas Chromatography
Carcinogens
Formaldehyde
Blood
High Pressure Liquid Chromatography

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

@article{5cbe3895370b4eb38d242c6baec2b698,
title = "Salivary levels of N-nitrosamines and some metabolites after IP injection of N-nitrosamines in rats",
abstract = "The carcinogens N-nitrosomethylamine (DMN) and N-nitrosodiethylamine (DEN) were detected in rat saliva by gas liquid chromatography or HPLC after their ip injections. Salivary levels were equal to or greater than blood levels. A fairly linear dose response in salivary levels was observed in the range of 1-50 mg/kg. Salivary levels of DMN and DEN decreased between 0.5 and 1.0 hr after administration with the decrease becoming more prominent at lower doses. Formaldehyde and bicarbonate, metabolites of DMN, were also detected in rat saliva.",
author = "Fliessbach, {J. H.} and Joseph Guttenplan",
year = "1981",
language = "English (US)",
volume = "33",
pages = "283--291",
journal = "Research Communications in Chemical Pathology and Pharmacology",
issn = "0034-5164",
publisher = "PJD Publications Ltd",
number = "2",

}

TY - JOUR

T1 - Salivary levels of N-nitrosamines and some metabolites after IP injection of N-nitrosamines in rats

AU - Fliessbach, J. H.

AU - Guttenplan, Joseph

PY - 1981

Y1 - 1981

N2 - The carcinogens N-nitrosomethylamine (DMN) and N-nitrosodiethylamine (DEN) were detected in rat saliva by gas liquid chromatography or HPLC after their ip injections. Salivary levels were equal to or greater than blood levels. A fairly linear dose response in salivary levels was observed in the range of 1-50 mg/kg. Salivary levels of DMN and DEN decreased between 0.5 and 1.0 hr after administration with the decrease becoming more prominent at lower doses. Formaldehyde and bicarbonate, metabolites of DMN, were also detected in rat saliva.

AB - The carcinogens N-nitrosomethylamine (DMN) and N-nitrosodiethylamine (DEN) were detected in rat saliva by gas liquid chromatography or HPLC after their ip injections. Salivary levels were equal to or greater than blood levels. A fairly linear dose response in salivary levels was observed in the range of 1-50 mg/kg. Salivary levels of DMN and DEN decreased between 0.5 and 1.0 hr after administration with the decrease becoming more prominent at lower doses. Formaldehyde and bicarbonate, metabolites of DMN, were also detected in rat saliva.

UR - http://www.scopus.com/inward/record.url?scp=0019401934&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019401934&partnerID=8YFLogxK

M3 - Article

C2 - 7302376

AN - SCOPUS:0019401934

VL - 33

SP - 283

EP - 291

JO - Research Communications in Chemical Pathology and Pharmacology

JF - Research Communications in Chemical Pathology and Pharmacology

SN - 0034-5164

IS - 2

ER -