Salivary gland disease in human immunodeficiency virus-positive women from the WIHS study

Roseann Mulligan, Mahvash Navazesh, Eugene Komaroff, Deborah Greenspan, Maryann Redford, Mario Alves, Joan Phelan

Research output: Contribution to journalArticle

Abstract

Objective. To determine the prevalence of enlargement, tenderness and absence of saliva on palpation as indicators of salivary gland disease in women who are human immunodeficiency virus (HIV)-positive. Study design. The study subjects are parti ci pants in the Women's Interagency HIV Study (WIHS), a multicenter study examining HIV-seropositive women and at-risk HIV-seronegative women. A total of 576 HIV-positive women and 152 HIV-negative women were examined at their baseline oral visit for clinical markers of salivary gland disease. Viral load levels, CD4 counts, and CD8 counts were obtained as part of the related core study. Results. HIV-positive women had higher rates of salivary gland enlargement (4.3%), tenderness (6.9%), and absence of saliva on palpation (26.6%) compared with HIV-negative women, who had rates of 1.3%, 4.6%, and 13.2%, respectively. Absence of saliva was significantly different (P = .001) between the 2 groups When 2 of the 3 clinical findings were combined, comparisons between the HIV-positive women and HIV-negative women became significant at the P < .05 level for every combination, except for enlargement/tenderness for the submandibular/sublingual gland. For the HIV-positive women, the viral load was significantly related to enlargement (P = .019) and enlargement/absence of saliva on palpation (P = .037) for the parotids and enlargement (P = .046), absence of saliva (P = .043), and enlargement/absence of saliva (P = .022) for the submandibular/sublingual glands. Sgnificant linear trends were found for increasing viral load and enlargement (P = .013) and enlargement/tenderness (P = .024) for the submandibular/sublingual glands. Sgnificance was present for submandibular/sublingual absence of saliva and tenderness/absence of saliva for CD4 and CD8 medians. Conclusions. Serostatus is related to salivary gland disease as assessed by glandular enlargement, tenderness, and absence of saliva on palpation. Furthermore, our findings indicate that a multidimensional approach to gland assessment may provide a more complete and perhaps more adequate description of glandular involvement with HIV infection.

Original languageEnglish (US)
Pages (from-to)702-709
Number of pages8
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume89
Issue number6
DOIs
StatePublished - 2000

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Salivary Gland Diseases
Saliva
HIV
Palpation
Sublingual Gland
Submandibular Gland
Viral Load
Virus Diseases
CD4 Lymphocyte Count
Salivary Glands

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery
  • Dentistry(all)

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Salivary gland disease in human immunodeficiency virus-positive women from the WIHS study. / Mulligan, Roseann; Navazesh, Mahvash; Komaroff, Eugene; Greenspan, Deborah; Redford, Maryann; Alves, Mario; Phelan, Joan.

In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, Vol. 89, No. 6, 2000, p. 702-709.

Research output: Contribution to journalArticle

Mulligan, Roseann ; Navazesh, Mahvash ; Komaroff, Eugene ; Greenspan, Deborah ; Redford, Maryann ; Alves, Mario ; Phelan, Joan. / Salivary gland disease in human immunodeficiency virus-positive women from the WIHS study. In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 2000 ; Vol. 89, No. 6. pp. 702-709.
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abstract = "Objective. To determine the prevalence of enlargement, tenderness and absence of saliva on palpation as indicators of salivary gland disease in women who are human immunodeficiency virus (HIV)-positive. Study design. The study subjects are parti ci pants in the Women's Interagency HIV Study (WIHS), a multicenter study examining HIV-seropositive women and at-risk HIV-seronegative women. A total of 576 HIV-positive women and 152 HIV-negative women were examined at their baseline oral visit for clinical markers of salivary gland disease. Viral load levels, CD4 counts, and CD8 counts were obtained as part of the related core study. Results. HIV-positive women had higher rates of salivary gland enlargement (4.3{\%}), tenderness (6.9{\%}), and absence of saliva on palpation (26.6{\%}) compared with HIV-negative women, who had rates of 1.3{\%}, 4.6{\%}, and 13.2{\%}, respectively. Absence of saliva was significantly different (P = .001) between the 2 groups When 2 of the 3 clinical findings were combined, comparisons between the HIV-positive women and HIV-negative women became significant at the P < .05 level for every combination, except for enlargement/tenderness for the submandibular/sublingual gland. For the HIV-positive women, the viral load was significantly related to enlargement (P = .019) and enlargement/absence of saliva on palpation (P = .037) for the parotids and enlargement (P = .046), absence of saliva (P = .043), and enlargement/absence of saliva (P = .022) for the submandibular/sublingual glands. Sgnificant linear trends were found for increasing viral load and enlargement (P = .013) and enlargement/tenderness (P = .024) for the submandibular/sublingual glands. Sgnificance was present for submandibular/sublingual absence of saliva and tenderness/absence of saliva for CD4 and CD8 medians. Conclusions. Serostatus is related to salivary gland disease as assessed by glandular enlargement, tenderness, and absence of saliva on palpation. Furthermore, our findings indicate that a multidimensional approach to gland assessment may provide a more complete and perhaps more adequate description of glandular involvement with HIV infection.",
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T1 - Salivary gland disease in human immunodeficiency virus-positive women from the WIHS study

AU - Mulligan, Roseann

AU - Navazesh, Mahvash

AU - Komaroff, Eugene

AU - Greenspan, Deborah

AU - Redford, Maryann

AU - Alves, Mario

AU - Phelan, Joan

PY - 2000

Y1 - 2000

N2 - Objective. To determine the prevalence of enlargement, tenderness and absence of saliva on palpation as indicators of salivary gland disease in women who are human immunodeficiency virus (HIV)-positive. Study design. The study subjects are parti ci pants in the Women's Interagency HIV Study (WIHS), a multicenter study examining HIV-seropositive women and at-risk HIV-seronegative women. A total of 576 HIV-positive women and 152 HIV-negative women were examined at their baseline oral visit for clinical markers of salivary gland disease. Viral load levels, CD4 counts, and CD8 counts were obtained as part of the related core study. Results. HIV-positive women had higher rates of salivary gland enlargement (4.3%), tenderness (6.9%), and absence of saliva on palpation (26.6%) compared with HIV-negative women, who had rates of 1.3%, 4.6%, and 13.2%, respectively. Absence of saliva was significantly different (P = .001) between the 2 groups When 2 of the 3 clinical findings were combined, comparisons between the HIV-positive women and HIV-negative women became significant at the P < .05 level for every combination, except for enlargement/tenderness for the submandibular/sublingual gland. For the HIV-positive women, the viral load was significantly related to enlargement (P = .019) and enlargement/absence of saliva on palpation (P = .037) for the parotids and enlargement (P = .046), absence of saliva (P = .043), and enlargement/absence of saliva (P = .022) for the submandibular/sublingual glands. Sgnificant linear trends were found for increasing viral load and enlargement (P = .013) and enlargement/tenderness (P = .024) for the submandibular/sublingual glands. Sgnificance was present for submandibular/sublingual absence of saliva and tenderness/absence of saliva for CD4 and CD8 medians. Conclusions. Serostatus is related to salivary gland disease as assessed by glandular enlargement, tenderness, and absence of saliva on palpation. Furthermore, our findings indicate that a multidimensional approach to gland assessment may provide a more complete and perhaps more adequate description of glandular involvement with HIV infection.

AB - Objective. To determine the prevalence of enlargement, tenderness and absence of saliva on palpation as indicators of salivary gland disease in women who are human immunodeficiency virus (HIV)-positive. Study design. The study subjects are parti ci pants in the Women's Interagency HIV Study (WIHS), a multicenter study examining HIV-seropositive women and at-risk HIV-seronegative women. A total of 576 HIV-positive women and 152 HIV-negative women were examined at their baseline oral visit for clinical markers of salivary gland disease. Viral load levels, CD4 counts, and CD8 counts were obtained as part of the related core study. Results. HIV-positive women had higher rates of salivary gland enlargement (4.3%), tenderness (6.9%), and absence of saliva on palpation (26.6%) compared with HIV-negative women, who had rates of 1.3%, 4.6%, and 13.2%, respectively. Absence of saliva was significantly different (P = .001) between the 2 groups When 2 of the 3 clinical findings were combined, comparisons between the HIV-positive women and HIV-negative women became significant at the P < .05 level for every combination, except for enlargement/tenderness for the submandibular/sublingual gland. For the HIV-positive women, the viral load was significantly related to enlargement (P = .019) and enlargement/absence of saliva on palpation (P = .037) for the parotids and enlargement (P = .046), absence of saliva (P = .043), and enlargement/absence of saliva (P = .022) for the submandibular/sublingual glands. Sgnificant linear trends were found for increasing viral load and enlargement (P = .013) and enlargement/tenderness (P = .024) for the submandibular/sublingual glands. Sgnificance was present for submandibular/sublingual absence of saliva and tenderness/absence of saliva for CD4 and CD8 medians. Conclusions. Serostatus is related to salivary gland disease as assessed by glandular enlargement, tenderness, and absence of saliva on palpation. Furthermore, our findings indicate that a multidimensional approach to gland assessment may provide a more complete and perhaps more adequate description of glandular involvement with HIV infection.

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