TY - JOUR
T1 - Salivary biomarkers associated with myocardial necrosis
T2 - Results from an alcohol septal ablation model
AU - Foley, Joseph D.
AU - Sneed, J. Darrell
AU - Steinhubl, Steven R.
AU - Kolasa, Justin R.
AU - Ebersole, Jeffrey L.
AU - Lin, Yushun
AU - Kryscio, Richard J.
AU - McDevitt, John T.
AU - Campbell, Charles L.
AU - Miller, Craig S.
PY - 2012/11/1
Y1 - 2012/11/1
N2 - Objective: To determine if salivary biomarkers demonstrate utility for identifying aspects of myocardial necrosis. Methods: Twenty-one patients undergoing alcohol septal ablation (ASA) for treatment of hypertrophic cardiomyopathy provided serum and unstimulated whole saliva at baseline and incremental time points post-ASA. Samples were analyzed for seven biomarkers related to myocardial damage, inflammation, and tissue remodeling using immunosorbent assays. Levels were compared with baseline and levels observed in 97 healthy controls. Results: Biomarkers of myocardial damage and inflammation (ie, troponin I, creatine kinase-MB, myoglobin, C-reactive protein) rose in serum 2- to 812-fold after ASA (P <.01). Significant elevations of 2.0- to 3.5-fold were observed with C-reactive protein and troponin I in saliva (P <.02). Significant correlations between levels in serum and saliva were observed for C-reactive protein, matrix metalloproteinase-9, and myeloperoxidase (P <.001). Conclusions: Select salivary biomarkers reflect changes that occur during, and subsequent to, myocardial necrosis caused by ASA.
AB - Objective: To determine if salivary biomarkers demonstrate utility for identifying aspects of myocardial necrosis. Methods: Twenty-one patients undergoing alcohol septal ablation (ASA) for treatment of hypertrophic cardiomyopathy provided serum and unstimulated whole saliva at baseline and incremental time points post-ASA. Samples were analyzed for seven biomarkers related to myocardial damage, inflammation, and tissue remodeling using immunosorbent assays. Levels were compared with baseline and levels observed in 97 healthy controls. Results: Biomarkers of myocardial damage and inflammation (ie, troponin I, creatine kinase-MB, myoglobin, C-reactive protein) rose in serum 2- to 812-fold after ASA (P <.01). Significant elevations of 2.0- to 3.5-fold were observed with C-reactive protein and troponin I in saliva (P <.02). Significant correlations between levels in serum and saliva were observed for C-reactive protein, matrix metalloproteinase-9, and myeloperoxidase (P <.001). Conclusions: Select salivary biomarkers reflect changes that occur during, and subsequent to, myocardial necrosis caused by ASA.
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U2 - 10.1016/j.oooo.2012.05.024
DO - 10.1016/j.oooo.2012.05.024
M3 - Article
C2 - 23021916
AN - SCOPUS:84867678149
VL - 114
SP - 616
EP - 623
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
SN - 2212-4403
IS - 5
ER -