Salivary biomarkers associated with myocardial necrosis

Results from an alcohol septal ablation model

Joseph D. Foley, J. Darrell Sneed, Steven R. Steinhubl, Justin R. Kolasa, Jeffrey L. Ebersole, Yushun Lin, Richard J. Kryscio, John McDevitt, Charles L. Campbell, Craig S. Miller

Research output: Contribution to journalArticle

Abstract

Objective: To determine if salivary biomarkers demonstrate utility for identifying aspects of myocardial necrosis. Methods: Twenty-one patients undergoing alcohol septal ablation (ASA) for treatment of hypertrophic cardiomyopathy provided serum and unstimulated whole saliva at baseline and incremental time points post-ASA. Samples were analyzed for seven biomarkers related to myocardial damage, inflammation, and tissue remodeling using immunosorbent assays. Levels were compared with baseline and levels observed in 97 healthy controls. Results: Biomarkers of myocardial damage and inflammation (ie, troponin I, creatine kinase-MB, myoglobin, C-reactive protein) rose in serum 2- to 812-fold after ASA (P

Original languageEnglish (US)
Pages (from-to)616-623
Number of pages8
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume114
Issue number5
DOIs
StatePublished - Nov 2012

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Necrosis
Biomarkers
Alcohols
Inflammation
MB Form Creatine Kinase
Immunosorbents
Troponin I
Myoglobin
Hypertrophic Cardiomyopathy
Serum
Saliva
C-Reactive Protein
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Radiology Nuclear Medicine and imaging
  • Dentistry (miscellaneous)

Cite this

Salivary biomarkers associated with myocardial necrosis : Results from an alcohol septal ablation model. / Foley, Joseph D.; Sneed, J. Darrell; Steinhubl, Steven R.; Kolasa, Justin R.; Ebersole, Jeffrey L.; Lin, Yushun; Kryscio, Richard J.; McDevitt, John; Campbell, Charles L.; Miller, Craig S.

In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 114, No. 5, 11.2012, p. 616-623.

Research output: Contribution to journalArticle

Foley, JD, Sneed, JD, Steinhubl, SR, Kolasa, JR, Ebersole, JL, Lin, Y, Kryscio, RJ, McDevitt, J, Campbell, CL & Miller, CS 2012, 'Salivary biomarkers associated with myocardial necrosis: Results from an alcohol septal ablation model', Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 114, no. 5, pp. 616-623. https://doi.org/10.1016/j.oooo.2012.05.024
Foley, Joseph D. ; Sneed, J. Darrell ; Steinhubl, Steven R. ; Kolasa, Justin R. ; Ebersole, Jeffrey L. ; Lin, Yushun ; Kryscio, Richard J. ; McDevitt, John ; Campbell, Charles L. ; Miller, Craig S. / Salivary biomarkers associated with myocardial necrosis : Results from an alcohol septal ablation model. In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2012 ; Vol. 114, No. 5. pp. 616-623.
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