Abstract
Objective: To determine if salivary biomarkers demonstrate utility for identifying aspects of myocardial necrosis. Methods: Twenty-one patients undergoing alcohol septal ablation (ASA) for treatment of hypertrophic cardiomyopathy provided serum and unstimulated whole saliva at baseline and incremental time points post-ASA. Samples were analyzed for seven biomarkers related to myocardial damage, inflammation, and tissue remodeling using immunosorbent assays. Levels were compared with baseline and levels observed in 97 healthy controls. Results: Biomarkers of myocardial damage and inflammation (ie, troponin I, creatine kinase-MB, myoglobin, C-reactive protein) rose in serum 2- to 812-fold after ASA (P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 616-623 |
| Number of pages | 8 |
| Journal | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology |
| Volume | 114 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 2012 |
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ASJC Scopus subject areas
- Surgery
- Oral Surgery
- Pathology and Forensic Medicine
- Radiology Nuclear Medicine and imaging
- Dentistry (miscellaneous)
Cite this
Salivary biomarkers associated with myocardial necrosis : Results from an alcohol septal ablation model. / Foley, Joseph D.; Sneed, J. Darrell; Steinhubl, Steven R.; Kolasa, Justin R.; Ebersole, Jeffrey L.; Lin, Yushun; Kryscio, Richard J.; McDevitt, John; Campbell, Charles L.; Miller, Craig S.
In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 114, No. 5, 11.2012, p. 616-623.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Salivary biomarkers associated with myocardial necrosis
T2 - Results from an alcohol septal ablation model
AU - Foley, Joseph D.
AU - Sneed, J. Darrell
AU - Steinhubl, Steven R.
AU - Kolasa, Justin R.
AU - Ebersole, Jeffrey L.
AU - Lin, Yushun
AU - Kryscio, Richard J.
AU - McDevitt, John
AU - Campbell, Charles L.
AU - Miller, Craig S.
PY - 2012/11
Y1 - 2012/11
N2 - Objective: To determine if salivary biomarkers demonstrate utility for identifying aspects of myocardial necrosis. Methods: Twenty-one patients undergoing alcohol septal ablation (ASA) for treatment of hypertrophic cardiomyopathy provided serum and unstimulated whole saliva at baseline and incremental time points post-ASA. Samples were analyzed for seven biomarkers related to myocardial damage, inflammation, and tissue remodeling using immunosorbent assays. Levels were compared with baseline and levels observed in 97 healthy controls. Results: Biomarkers of myocardial damage and inflammation (ie, troponin I, creatine kinase-MB, myoglobin, C-reactive protein) rose in serum 2- to 812-fold after ASA (P
AB - Objective: To determine if salivary biomarkers demonstrate utility for identifying aspects of myocardial necrosis. Methods: Twenty-one patients undergoing alcohol septal ablation (ASA) for treatment of hypertrophic cardiomyopathy provided serum and unstimulated whole saliva at baseline and incremental time points post-ASA. Samples were analyzed for seven biomarkers related to myocardial damage, inflammation, and tissue remodeling using immunosorbent assays. Levels were compared with baseline and levels observed in 97 healthy controls. Results: Biomarkers of myocardial damage and inflammation (ie, troponin I, creatine kinase-MB, myoglobin, C-reactive protein) rose in serum 2- to 812-fold after ASA (P
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U2 - 10.1016/j.oooo.2012.05.024
DO - 10.1016/j.oooo.2012.05.024
M3 - Article
VL - 114
SP - 616
EP - 623
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
SN - 2212-4403
IS - 5
ER -