Safety of thrombolysis in patients over the age of 80

Joshua Zebadiah Willey, Nils Petersen, Mandip S. Dhamoon, Joshua Stillman, Bernadette Boden-Albala, Mitchell S V Elkind, Randolph S. Marshall

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The safety of intravenous thrombolysis (IVT) in patients with acute ischemic stroke over the age of 80 is unclear. We hypothesized that patients over the age of 80 can be safely treated with IVT. METHODS: Admission and discharge data were collected on all patients at a single tertiary care center presenting within 12 hours of onset. Collected data included treatment with IVT, demographics, pretreatment National Institutes of Health Stroke Scale score, length of stay, mortality, and discharge disposition. Analyses were restricted to patients over the age of 80, and the primary outcome was in-hospital mortality. Logistic regression was used to examine whether IVT was associated with mortality. RESULTS: Between January 1, 2005 and May 30, 2010, 112 patients over the age of 80 presented within 3 hours of ischemic stroke onset, and 31 received IVT. There were 15 deaths. In multivariable models adjusted for age, sex, race-ethnicity, and National Institutes of Health Stroke Scale, treatment with IVT, compared with no treatment, was not associated with in-hospital death (adjusted odds ratio, 1.2; 95% confidence interval, 0.3-4.3). CONCLUSIONS: Treating ischemic stroke patients over 80 years with IVT was not associated with an increase in mortality in an urban tertiary care center.

Original languageEnglish (US)
Pages (from-to)99-101
Number of pages3
JournalNeurologist
Volume18
Issue number2
DOIs
StatePublished - Mar 2012

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Safety
Stroke
National Institutes of Health (U.S.)
Tertiary Care Centers
Mortality
Hospital Mortality
Length of Stay
Therapeutics
Logistic Models
Odds Ratio
Demography
Confidence Intervals

Keywords

  • geriatric
  • stroke
  • thrombolysis

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Willey, J. Z., Petersen, N., Dhamoon, M. S., Stillman, J., Boden-Albala, B., Elkind, M. S. V., & Marshall, R. S. (2012). Safety of thrombolysis in patients over the age of 80. Neurologist, 18(2), 99-101. https://doi.org/10.1097/NRL.0b013e318248ea3c

Safety of thrombolysis in patients over the age of 80. / Willey, Joshua Zebadiah; Petersen, Nils; Dhamoon, Mandip S.; Stillman, Joshua; Boden-Albala, Bernadette; Elkind, Mitchell S V; Marshall, Randolph S.

In: Neurologist, Vol. 18, No. 2, 03.2012, p. 99-101.

Research output: Contribution to journalArticle

Willey, JZ, Petersen, N, Dhamoon, MS, Stillman, J, Boden-Albala, B, Elkind, MSV & Marshall, RS 2012, 'Safety of thrombolysis in patients over the age of 80', Neurologist, vol. 18, no. 2, pp. 99-101. https://doi.org/10.1097/NRL.0b013e318248ea3c
Willey JZ, Petersen N, Dhamoon MS, Stillman J, Boden-Albala B, Elkind MSV et al. Safety of thrombolysis in patients over the age of 80. Neurologist. 2012 Mar;18(2):99-101. https://doi.org/10.1097/NRL.0b013e318248ea3c
Willey, Joshua Zebadiah ; Petersen, Nils ; Dhamoon, Mandip S. ; Stillman, Joshua ; Boden-Albala, Bernadette ; Elkind, Mitchell S V ; Marshall, Randolph S. / Safety of thrombolysis in patients over the age of 80. In: Neurologist. 2012 ; Vol. 18, No. 2. pp. 99-101.
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