Routine quantitative analysis of brain and cerebrospinal fluid spaces with MR imaging

Ron Kikinis, Martha E. Shenton, Guido Gerig, John Martin, Mark Anderson, David Metcalf, Charles R.G. Guttmann, Robert W. McCarley, Ferenc A. Jolesz, William Lorensen, Harvey Cline

    Research output: Contribution to journalArticle

    Abstract

    A computerized system for processing spin‐echo magnetic resonance (MR) imaging data was implemented to estimate whole brain (gray and white matter) and cerebrospinal fluid volumes and to display three‐dimensional surface reconstructions of specified tissue classes. The techniques were evaluated by assessing the radiometric variability of MR volume data and by comparing automated and manual procedures for measuring tissue volumes. Results showed (a) the homogeneity of the MR data and (b) that automated techniques were consistently superior to manual techniques. Both techniques, however, were affected by the complexity of the structure, with simpler structures (eg, the intracranial cavity) showing less variability and better spatial correlation of segmentation results between raters. Moreover, the automated techniques were completed for whole brain in a fraction of the time required to complete the equivalent segmentation manually. Additional evaluations included interrater reliability and an evaluation that included longitudinal measurement, in which one subject was imaged sequentially 24 times, with reliability computed from data collected by three raters over 1 year. Results showed good reliability for the automated segmentation procedures.

    Original languageEnglish (US)
    Pages (from-to)619-629
    Number of pages11
    JournalJournal of Magnetic Resonance Imaging
    Volume2
    Issue number6
    DOIs
    StatePublished - Jan 1 1992

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    Keywords

    • Brain. MR, 10.1214
    • Cerebrospinal fluid, MR. 10.1214
    • Comparative studies
    • Image display
    • Image processing
    • Three‐dimensional imaging
    • Volume measurement

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

    Cite this

    Kikinis, R., Shenton, M. E., Gerig, G., Martin, J., Anderson, M., Metcalf, D., Guttmann, C. R. G., McCarley, R. W., Jolesz, F. A., Lorensen, W., & Cline, H. (1992). Routine quantitative analysis of brain and cerebrospinal fluid spaces with MR imaging. Journal of Magnetic Resonance Imaging, 2(6), 619-629. https://doi.org/10.1002/jmri.1880020603