Role of topological restrictions in the kinetics of collapse of a homopolymer and in the self-organization of biopolymers

A. Yu Grosberg, S. K. Nechayev, Ye I. Shakhnovich

    Research output: Contribution to journalArticle

    Abstract

    The rapid collapse of a linear homopolymer after abrupt fall in temperature or deterioration of the quality of the solvent leads to the advent of a folded non-equilibrium globule. The length of the chain in it is a fractal with the dimension μ ≤ 2 on small and μ = 3 on large scales. This is ensured by the non-self-intersection of the chain and the resulting spatial segregation from each other on all itself. Further relaxation of the folded globule occurs very slowly, only through reptation (diffusion crawling) of the chain along itself and leads to knotting of the polymer. The model of the folded globule makes it possible to explain from a consistent standpoint a whole number of properties of globular proteins. Predictions, the verification of which in the real or computer experiment should demonstrate the adequacy of our results, are formulated.

    Original languageEnglish (US)
    Pages (from-to)265-272
    Number of pages8
    JournalBiophysics
    Volume33
    Issue number2
    StatePublished - 1988

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    Fractals
    Biopolymers
    Polymers
    Temperature
    Proteins

    ASJC Scopus subject areas

    • Biophysics

    Cite this

    Role of topological restrictions in the kinetics of collapse of a homopolymer and in the self-organization of biopolymers. / Grosberg, A. Yu; Nechayev, S. K.; Shakhnovich, Ye I.

    In: Biophysics, Vol. 33, No. 2, 1988, p. 265-272.

    Research output: Contribution to journalArticle

    Grosberg, A. Yu ; Nechayev, S. K. ; Shakhnovich, Ye I. / Role of topological restrictions in the kinetics of collapse of a homopolymer and in the self-organization of biopolymers. In: Biophysics. 1988 ; Vol. 33, No. 2. pp. 265-272.
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